Synthetic Pyrethroids Exposure and Embryological Outcomes: A Cohort Study in Women from Fertility Clinic

Paweł Radwan, Bartosz Wielgomas, Michał Radwan, Rafał Krasiński, Anna Kilanowicz-Sapota, Renata Banaszczyk and Joanna Jurewicz
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Paweł Radwan: Gameta Health Centre, 7 Cybernetyki St., 02-677 Warsaw, Poland
Bartosz Wielgomas: Department of Toxicology, Medical University of Gdańsk, 107 Hallera St., 80-416 Gdansk, Poland
Michał Radwan: Department of Gynecology and Reproduction, Gameta Hospital, 34/36 Rudzka St., 95-030 Rzgow, Poland
Rafał Krasiński: Department of Gynecology and Reproduction, Gameta Hospital, 34/36 Rudzka St., 95-030 Rzgow, Poland
Anna Kilanowicz-Sapota: Department of Toxicology, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz, Poland
Renata Banaszczyk: Department of Gynecology and Reproduction, Gameta Hospital, 34/36 Rudzka St., 95-030 Rzgow, Poland
Joanna Jurewicz: Department of Chemical Safety, Nofer Institute of Occupational Medicine, 8 Teresy St., 91-348 Lodz, Poland

IJERPH, 2022, vol. 19, issue 9, 1-10

Abstract: Pyrethroids exposure has been associated with adverse reproductive outcome. However, there is no study that explores the effect of environmental exposure and embryological outcomes. This question was addressed in a prospective cohort of couples undergoing fertility treatment. The study aims to assess the association between urinary metabolites of synthetic pyrethroids and embryological outcomes (MII oocyte count, top quality embryo, fertilization and implantation rate). We included 450 women aged 25–45 undergoing assisted reproductive technology (ART) cycle at Infertility Clinic in Poland. Urine samples were collected at the time of fertility procedure(s) to assess four urinary synthetic pyrethroids concentrations (3-phenoxybenzoic acid (3PBA), cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (cis-DCCA), trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (trans-DCCA), cis-2,2-dibromovinyl-2,2-dimethylocyclopropane-1-carboxylic acid (DBCA)) using validated gas chromatography ion-tap mass spectrometry and calculated for each cycle-specific metabolite. To evaluate the effect of environmental exposure to synthetic pyrethroids and embryological outcomes (methaphase II (MII) oocyte yield, top quality embryo, fertilization rate, implantation rate), multivariable generalized linear mixed analyses with random intercepts were prepared. Urinary 3-PBA concentrations decrease MII oocyte count ( p = 0.007) in the fourth quartile (>75 percentile) compared to women in the first quartile (≤25 percentile). Additionally, when 3-PBA was treated as continuous variable, the negative association between exposure to pyrethroids and MII oocyte count was also observed ( p = 0.012). Exposure to other pyrethroid metabolities (CDCCA, TDCCA, DBCA) was not related to any of the examined embryological outcomes. Exposure to synthetic pyrethroids may be associated with poorer embryological outcome among couples seeking fertility treatments. As this is the first study on this topic, the results need to be confirmed in further studies.

Keywords: embryological outcomes; urinary pyrethroids concentrations; environmental exposure; IVF treatment (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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