Persistence of Adverse Drug Reaction-Related Hospitalization Risk Following Discharge

Olive Schmid, Bonnie Bereznicki, Gregory Mark Peterson, Jim Stankovich and Luke Bereznicki
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Olive Schmid: School of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7001, Australia
Bonnie Bereznicki: Tasmanian School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia
Gregory Mark Peterson: School of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7001, Australia
Jim Stankovich: School of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7001, Australia
Luke Bereznicki: School of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7001, Australia

IJERPH, 2022, vol. 19, issue 9, 1-12

Abstract: This retrospective cohort study analyzed the administrative hospital records of 91,500 patients with the aim of assessing adverse drug reaction (ADR)-related hospital admission risk after discharge from ADR and non-ADR-related admission. Patients aged ≥18 years with an acute admission to public hospitals in Tasmania, Australia between 2011 and 2015 were followed until May 2017. The index admissions ( n = 91,550) were stratified based on whether they were ADR-related ( n = 2843, 3.1%) or non-ADR-related ( n = 88,707, 96.9%). Survival analysis assessed the post-index ADR-related admission risk using (1) the full dataset, and (2) a matched subset of patients using a propensity score analysis. Logistic regression was used to identify the risk factors for ADR-related admissions within 90 days of post-index discharge. The patients with an ADR-related index admission were almost five times more likely to experience another ADR-related admission within 90 days ( p < 0.001). An increased risk persisted for at least 5 years ( p < 0.001), which was substantially longer than previously reported. From the matched subset of patients, the risk of ADR-related admission within 90 and 365 days more than doubled in the patients with an ADR-related index admission ( p < 0.0001). These admissions were often attributed to the same drug class as the patients’ index ADR-related admission. Cancer was a major risk factor for ADR-related re-hospitalization within 90 days; other factors included heart failure and increasing age.

Keywords: adverse drug reactions; medication errors; medication safety; adverse drug event; hospital admission; risk factors (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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