Treatment of Peri-Implant Mucositis with Standard of Care and Bioptron Hyperlight Therapy: A Randomized Clinical Trial

Gianna Maria Nardi, Marta Mazur, Giulio Papa, Massimo Petruzzi, Felice Roberto Grassi and Roberta Grassi
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Gianna Maria Nardi: Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy
Marta Mazur: Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy
Giulio Papa: Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy
Massimo Petruzzi: Interdisciplinary Department of Medicine, Aldo Moro University of Bari, 70121 Bari, Italy
Felice Roberto Grassi: Department of Basic Medical Sciences, Neurosciences and Sense Organs, Aldo Moro University of Bari, 70122 Bari, Italy
Roberta Grassi: Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy

IJERPH, 2022, vol. 19, issue 9, 1-13

Abstract: The aim of this study was to evaluate in a cohort of patients with peri-implant mucositis: (a) the efficacy of professional mechanical debridement therapy assisted using Bioptron Hyperlight Therapy on the reduction in periodontal indexes and (b) the reduction in total oxidative salivary stress. Forty subjects with a diagnosis of peri-implant mucositis were enrolled and randomly assigned to the Study Group (mechanical debridement therapy assisted using Bioptron Hyperlight Therapy) or Control Group (mechanical debridement therapy alone). The study duration was 6 months. Data on plaque index (PI), bleeding on probing (BoP), probing pocket depth (PPD), and pain relief on Visual Analogue Scale (VAS) were recorded at T 0 , T 1 (14 days), T 2 (1 month), and T 3 (6 months). Group differences were assessed using Student’s t -test and Pearson’s Chi-squared test of homogeneity. PI and PPD decreased in the Study Group at the [T 0 ; T 1 ] time interval and during the overall time of observation significantly more than in the Control Group; BoP and pain on VAS decreased significantly faster in the Study Group than in the Control Group. Differences in Salivary Antioxidant Test (SAT) changes were not significant at any time interval. Patients’ gender and smoking habit were not correlated with the clinical outcomes. Clinical parameters related to peri-implant mucositis significantly improved in the Study Group, which demonstrated the clinical efficacy of the Bioptron Hyperlight Therapy as an adjunct to standard of care for the treatment of peri-implant mucositis. The RCT was registered at the US National Institutes of Health #NCT05307445.

Keywords: peri-implant mucositis; dental implants; clinical trial; Bioptron; oxidative stress; photobiomodulation; SAT; non-surgical periodontal therapy; dental hygiene; salivary test (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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