Oxygen–Ozone Therapy Associated with Alpha Lipoic Acid Plus Palmitoylethanolamide and Myrrh versus Ozone Therapy in the Combined Treatment of Sciatic Pain Due to Herniated Discs: Observational Study on 318 Patients

Matteo Bonetti, Dorina Lauritano, Gian Maria Ottaviani, Alessandro Fontana, Alessio Zambello, Luigi Della Gatta, Mario Muto and Francesco Carinci
Additional contact information
Matteo Bonetti: Neuroradiology Service Istituto Clinico Città di Brescia, 25128 Brescia, Italy
Dorina Lauritano: Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy
Gian Maria Ottaviani: Emergency and Urgency Department, Spedali Civili di Brescia, 25123 Brescia, Italy
Alessandro Fontana: Neuroradiology Service Istituto Clinico Città di Brescia, 25128 Brescia, Italy
Alessio Zambello: Anesthesia and Pain Therapy Service, Casa di Cura Borghi, 21020 Brebbia, Italy
Luigi Della Gatta: Neuroradiology Department, Ospedale Cardarelli Napoli, 80131 Napoli, Italy
Mario Muto: Neuroradiology Department, Ospedale Cardarelli Napoli, 80131 Napoli, Italy
Francesco Carinci: Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy

IJERPH, 2022, vol. 19, issue 9, 1-9

Abstract: Background: The aim of our observational study is to compare the therapeutic efficacy of combined treatment of oxygen–ozone therapy and oral treatment with alpha-lipoic acid (ALA) + palmitoylethanolamide (PEA) and myrrh in patients with peripheral neuropathic pain (sciatica) on radicular disc conflict from disc herniation and the results obtained with oxygen–ozone treatment alone. Methods: We enrolled 318 patients with the neuroradiological diagnosis of disc herniation performed with computed tomography (CT) or magnetic resonance imaging (MRI) and symptoms characterized by low back pain complicated by sciatica, which we divided into two groups. Group A was composed of 165 patients who were treated only with oxygen–ozone therapy with CT-guided intraforaminal technique, while the remaining 153 (Group B) have undergone combined oral treatment with ALA + PEA and myrrh. Follow-up visits for the evaluation of the clinical outcome of the treatment were conducted after 60 ± 8 days using a modified version of McNab’s method. Results: At the clinical check-up, 126/165 patients included in Group A had a complete remission of pain (76.4%), while in Group B, 119/153 (77.8%) had a complete remission of pain. Conclusion: The results highlight how the treatment associated with ozone therapy and oral administration of alpha-lipoic acid + palmitoylethanolamide and myrrh is preferred over the simple treatment with only ozone in such patients in the phase of greatest acuity of the disease, where the pain appears to be better controlled.

Keywords: lumbar disk herniation; ozone therapy; ozone; alpha-lipoic acid; palmitoylethanolamide; myrrh (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/19/9/5716/pdf (application/pdf)
https://www.mdpi.com/1660-4601/19/9/5716/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:19:y:2022:i:9:p:5716-:d:810797

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().