Modeling di (2-ethylhexyl) Phthalate (DEHP) and Its Metabolism in a Body’s Organs and Tissues through Different Intake Pathways into Human Body

Ao Li, Lingyi Kang, Runjie Li, Sijing Wu, Ke Liu and Xinke Wang
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Ao Li: School of Human Settlements and Civil Engineering, Xi’an Jiaotong University, Xi’an 710049, China
Lingyi Kang: School of Human Settlements and Civil Engineering, Xi’an Jiaotong University, Xi’an 710049, China
Runjie Li: School of Human Settlements and Civil Engineering, Xi’an Jiaotong University, Xi’an 710049, China
Sijing Wu: School of Human Settlements and Civil Engineering, Xi’an Jiaotong University, Xi’an 710049, China
Ke Liu: School of Human Settlements and Civil Engineering, Xi’an Jiaotong University, Xi’an 710049, China
Xinke Wang: School of Human Settlements and Civil Engineering, Xi’an Jiaotong University, Xi’an 710049, China

IJERPH, 2022, vol. 19, issue 9, 1-15

Abstract: Phthalate esters (PAEs) are ubiquitous in indoor environments as plasticizers in indoor products. Residences are often exposed to indoor PAEs in the form of gas, particles, settled dust, and surface phases. To reveal the mechanism behind the accumulation of PAEs in different tissues or organs such as the liver and the lungs when a person exposed to indoor PAEs with different phases, a whole-body physiologically based pharmacokinetic model for PAEs is employed to characterize the dynamic process of phthalates by different intake pathways, including oral digestion, dermal adsorption, and inhalation. Among three different intake pathways, dermal penetration distributed the greatest accumulation of DEHP in most of the organs, while the accumulative concentration through oral ingestion was an order of magnitude lower than the other two doses. Based on the estimated parameters, the variation of di-ethylhexyl phthalate (DEHP) and mono (2-ethylhexyl) phthalate (MEHP) concentration in the venous blood, urine, the liver, the thymus, the pancreas, the spleen, the lungs, the brain, the heart, and the kidney for different intake scenarios was simulated. The simulated results showed a different accumulation profile of DEHP and MEHP in different organs and tissues and demonstrated that the different intake pathways will result in different accumulation distributions of DEHP and MEHP in organs and tissues and may lead to different detrimental health outcomes.

Keywords: exposure; indoor; metabolism; PBPK model; phthalate esters (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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