The Relationship between Exposure to Airborne Particulate and DNA Adducts in Blood Cells in an Urban Population of Subjects with an Unhealthy Body Mass Index

Alessandra Pulliero, Simona Iodice, Angela Cecilia Pesatori, Luisella Vigna, Zumama Khalid, Valentina Bollati and Alberto Izzotti
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Alessandra Pulliero: Department of Health Sciences, University of Genoa, 16132 Genoa, Italy
Simona Iodice: Epiget Lab, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy
Angela Cecilia Pesatori: Epiget Lab, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy
Luisella Vigna: Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
Zumama Khalid: Department of Health Sciences, University of Genoa, 16132 Genoa, Italy
Valentina Bollati: Epiget Lab, Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy
Alberto Izzotti: Department of Experimental Medicine, University of Genoa, 16132 Genoa, Italy

IJERPH, 2022, vol. 19, issue 9, 1-12

Abstract: Bulky DNA adducts are a combined sign of aromatic chemical exposure, as well as an individual’s ability to metabolically activate carcinogens and repair DNA damage. The present study aims to investigate the association between PM exposure and DNA adducts in blood cells, in a population of 196 adults with an unhealthy BMI (≥25). For each subject, a DNA sample was obtained for quantification of DNA adducts by sensitive 32 P post-labelling methods. Individual PM 10 exposure was derived from daily mean concentrations measured by single monitors in the study area and then assigned to each subject by calculating the mean of the 30 days (short-term exposure), and of the 365 (long-term exposure) preceding enrolment. Multivariable linear regression models were used to study the association between PM 10 and DNA adducts. The majority of analysed samples had bulky DNA adducts, with an average value of 3.7 ± 1.6 (mean ± SD). Overall, the findings of the linear univariate and multiple linear regression showed an inverse association between long-term PM 10 exposure and adduct levels; this unexpected result might be since the population consists of subjects with an unhealthy BMI, which might show an atypical reaction to airborne urban pollutants; a hermetic response which happens when small amounts of pollutants are present. Pollutants can linger for a long time in the adipose tissue of obese persons, contributing to an increase in oxidative DNA damage, inflammation, and thrombosis when exposure is sustained.

Keywords: airborne particulate; DNA adducts; blood; overweight; BMI (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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