Liver and Renal Function Tests in Artisans Occupationally Exposed to Lead in Mechanic Village in Nnewi, Nigeria

C. E. Dioka, O. E. Orisakwe, F. A.A. Adeniyi and S. C. Meludu
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C. E. Dioka: Department of Chemical Pathology, College of Medicine, University of Ibadan, Nigeria
O. E. Orisakwe: Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, P.M.B 5001, Nnewi, Anambra State, Nigeria
F. A.A. Adeniyi: Department of Chemical Pathology, College of Medicine, University of Ibadan, Nigeria
S. C. Meludu: Dept of Human Biochemistry, College of Health Sciences, Nnamdi Azikiwe University, P.M.B 5001, Nnewi, Anambra State, Nigeria

IJERPH, 2004, vol. 1, issue 1, 1-5

Abstract: Additives in petroleum solvents have been reported to have adverse health implications. An evaluation study on some toxicological effects of occupational exposure to petroleum products (especially petrol which contains tetraethyl lead) amongst twenty five occupationally exposed artisans and twenty five graduate students of College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Nigeria as controls, was carried out using the following biochemical markers: electrolytes, urea, uric acid, inorganic phosphorus, creatinine, zinc and blood lead, as well as the activities of alanine and aspartate aminotransferases, and alkaline phosphatase. The results showed that occupational exposure of human subjects to lead in petrol increases the concentrations of uric acid (357 ± 123? mol/L) and phosphate (1.5 ± 0.5m mol/L) in exposed subjects compared with unexposed subjects (uric acid 228 ± 105? mol/L, phosphate 1.2 ± 0.41m mol/L; p

Keywords: Nigeria; Artisans; petrolium; lead; liver; kidney; biomarkers (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2004
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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