Impact of Mineralocorticoid Receptor Gene NR3C2 on the Prediction of Functional Classification of Left Ventricular Remodeling and Arrhythmia after Acute Myocardial Infarction

Rima Braukyliene (), Ali Aldujeli, Ayman Haq, Laurynas Maciulevicius, Darija Jankauskaite, Martynas Jurenas, Ramunas Unikas, Vytautas Zabiela, Vaiva Lesauskaite, Sandrita Simonyte and Diana Zaliaduonytė
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Rima Braukyliene: Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania
Ali Aldujeli: Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania
Ayman Haq: Minneapolis Heart Institute, 800 E 28th St Heart Hospital Minneapolis, Minneapolis, MN 55407, USA
Laurynas Maciulevicius: Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania
Darija Jankauskaite: Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania
Martynas Jurenas: Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania
Ramunas Unikas: Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania
Vytautas Zabiela: Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania
Vaiva Lesauskaite: Laboratory of Molecular Cardiology, Lithuanian University of Health Sciences, Sukileliu 15, 50162 Kaunas, Lithuania
Sandrita Simonyte: Laboratory of Molecular Cardiology, Lithuanian University of Health Sciences, Sukileliu 15, 50162 Kaunas, Lithuania
Diana Zaliaduonytė: Department of Cardiology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus 9, 44307 Kaunas, Lithuania

IJERPH, 2022, vol. 20, issue 1, 1-13

Abstract: Background: The NR3C2 gene encodes the mineralocorticoid receptor, which is present on cardiomyocytes. Prior studies reported an association between the presence of NR3C2 single-nucleotide polymorphisms (SNPs) and an increased cortisol production during a stress response such as acute myocardial infarction (AMI), which may lead to adverse cardiac remodeling. Objective: To study the impact of the NR3C2 rs2070950, rs4635799 and rs5522 gene polymorphisms on left ventricular (LV) remodeling, rhythm and conduction disorders in AMI patients. Methods: A cohort of 301 AMI patients who underwent revascularization was included. SNPs of the NR3C2 gene (rs2070950, rs4635799 and rs5522) were evaluated. A total of 127 AMI patients underwent transthoracic echocardiography follow-up after 72 h and 6 months. Results: The rs2070950 GG genotype and rs4635799 TT genotype were most common in patients who had LV end-diastolic volume increase < 20% and the same or increased LV ejection fraction, indicating a possible protective effect of these SNPs. The rs5522 TT genotype was associated with a higher frequency of arrhythmias, while the presence of at least one rs5522 C allele was associated with a lower risk of arrhythmias. Conclusion: SNPs of the NR3C2 gene appear to correlate with better ventricular remodeling and a reduced rate of arrhythmias post-AMI, possibly by limiting the deleterious effects of cortisol on cardiomyocytes.

Keywords: NR3C2 gene; acute myocardial infarction; mineralocorticoid receptor; rs5522; rs4635799; rs2070950 (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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