Factors Determining the Agreement between Aerobic Threshold and Point of Maximal Fat Oxidation: Follow-Up on a Systematic Review and Meta-Analysis on Association

Carlo Ferri Marini, Philippe Tadger, Isaac Armando Chávez-Guevara, Elizabeth Tipton, Marco Meucci, Zoran Nikolovski, Francisco Jose Amaro-Gahete and Ratko Peric ()
Additional contact information
Carlo Ferri Marini: Department of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy
Philippe Tadger: Real World Evidence, IQVIA, 3600 Genk, Belgium
Isaac Armando Chávez-Guevara: Department of Chemical Sciences, Biomedical Sciences Institute, Ciudad Juarez Autonomous University, Chihuahua 32310, Mexico
Elizabeth Tipton: Department of Statistics and Data Science, Northwestern University, Evanston, IL 60208, USA
Marco Meucci: Department of Health and Exercise Science, Appalachian State University, Boone, NC 28608, USA
Zoran Nikolovski: Faculty of Kinesiology, University of Split, 21000 Split, Croatia
Francisco Jose Amaro-Gahete: Department of Physiology, Faculty of Medicine, University of Granada, 18001 Granada, Spain
Ratko Peric: Department for Exercise Physiology, Orthopedic Clinic Orthosport, 78000 Banja Luka, Bosnia and Herzegovina

IJERPH, 2022, vol. 20, issue 1, 1-15

Abstract: Regular exercise at the intensity matching maximal fat oxidation (FAT max ) has been proposed as a key element in both athletes and clinical populations when aiming to enhance the body’s ability to oxidize fat. In order to allow a more standardized and tailored training approach, the connection between FAT max and the individual aerobic thresholds (AerT) has been examined. Although recent findings strongly suggest that a relationship exists between these two intensities, correlation alone is not sufficient to confirm that the intensities necessarily coincide and that the error between the two measures is small. Thus, this systematic review and meta-analysis aim to examine the agreement levels between the exercise intensities matching FAT max and AerT by pooling limits of agreement in a function of three parameters: (i) the average difference, (ii) the average within-study variation, and (iii) the variation in bias across studies, and to examine the influence of clinical and methodological inter- and intra-study differences on agreement levels. This study was registered with PROSPERO (CRD42021239351) and ClinicalTrials (NCT03789045). PubMed and Google Scholar were searched for studies examining FAT max and AerT connection. Overall, 12 studies with forty-five effect sizes and a total of 774 subjects fulfilled the inclusion criteria. The ROBIS tool for risk of bias assessment was used to determine the quality of included studies. In conclusion, the overall 95% limits of agreement of the differences between FAT max and AerT exercise intensities were larger than the a priori determined acceptable agreement due to the large variance caused by clinical and methodological differences among the studies. Therefore, we recommend that future studies follow a strict standardization of data collection and analysis of FAT max - and AerT-related outcomes.

Keywords: peak fat oxidation; aerobic threshold; exercise; agreement (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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