Underdiagnosis in Background of Emerging Public Health Challenges Related to Peri-Implant Diseases: An Interventional Split-Mouth Study

Boris Djuran, Zoran Tatic, Neda Perunovic, Natasa Pejcic, Jovana Vukovic, Aleksandra Petkovic-Curcin, Danilo Vojvodic and Mia Rakic ()
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Boris Djuran: Department of Oral Implantology, Military Medical Academy, 11000 Belgrade, Serbia
Zoran Tatic: Department of Oral Implantology, Military Medical Academy, 11000 Belgrade, Serbia
Neda Perunovic: Faculty of Dental Medicine, University of Belgrade, 11000 Belgrade, Serbia
Natasa Pejcic: Faculty of Dental Medicine, University of Belgrade, 11000 Belgrade, Serbia
Jovana Vukovic: Biocell Hospital, 11070 Beograd, Serbia
Aleksandra Petkovic-Curcin: Institute for Medical Research, Military Medical Academy, 11000 Belgrade, Serbia
Danilo Vojvodic: Institute for Medical Research, Military Medical Academy, 11000 Belgrade, Serbia
Mia Rakic: ETEP (Etiology and Therapy of Periodontal Diseases) Research Group, University Complutense of Madrid, 28040 Madrid, Spain

IJERPH, 2022, vol. 20, issue 1, 1-11

Abstract: Peri-implant diseases are an emerging public health problem, and it’s considered that limitations of standard diagnostics play the role herein. The study objective was the estimation of pathological bone resorption at clinical and biological level in patients with peri-implant mucositis (PIM) and peri-implantitis (PI) before and 6 months after standard treatment and to compare them with healthy controls (HC). The split-mouth interventional study included 60 patients affected with PIM or PI. Patients that also presented at least one more HC were enrolled in the study and underwent standard non-surgical and surgical treatment, respectively. Standard clinical parameters and soluble levels of RANKL were measured in peri-implant crevicular fluid baseline and 6 months following treatment. Clinical parameters and RANKL significantly decreased following treatment in PIM and PI. However, bleeding on probing and probing depth remained significantly increased when compared to HC. RANKL answered requests for biomarker of peri-implant diseases, its baseline levels were significantly increased in PIM and PI, they decreased following treatment and reached HC in peri-implantitis, while in PIM RANKL remained significantly increased. Presence of pathological bone resorption in patients lacked its clinical signs, and respective persistence following treatment suggest the need for biomarker-supported diagnosis for timely diagnosis of peri-implantitis and appropriate orientation of respective management strategies.

Keywords: peri-implant diseases; peri-implantitis; peri-implant mucositis; biomarker; treatment; bone loss; precision medicine; early diagnosis; public health (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:20:y:2022:i:1:p:477-:d:1017530

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