Are COL22A1 Gene Polymorphisms rs11784270 and rs6577958 Associated with Susceptibility to a Non-Contact Anterior Cruciate Ligament Injury in Polish Athletes?

Zhuo Sun, Paweł Cięszczyk, Ewelina Lulińska, Magdalena Dzitkowska-Zabielska, Monika Johne (), Kinga Humińska-Lisowska, Monika Michałowska-Sawczyn, Krzysztof Ficek, Agata Leońska-Duniec, Andrzej Mastalerz, Arkadiusz Janczyk and Sawczuk Marek
Additional contact information
Zhuo Sun: Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
Paweł Cięszczyk: Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
Ewelina Lulińska: Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
Magdalena Dzitkowska-Zabielska: Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
Monika Johne: Faculty of Physical Education, Jozef Pilsudski University of Physical Education in Warsaw, 00-809 Warsaw, Poland
Kinga Humińska-Lisowska: Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
Monika Michałowska-Sawczyn: Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
Krzysztof Ficek: Faculty of Physiotherapy, The Jerzy Kukuczka Academy of Physical Education in Katowice, 40-065 Katowice, Poland
Agata Leońska-Duniec: Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
Andrzej Mastalerz: Faculty of Physical Education, Jozef Pilsudski University of Physical Education in Warsaw, 00-809 Warsaw, Poland
Arkadiusz Janczyk: Center for Physiotherapy, Military Unit No. 6021, 01-001 Warsaw, Poland
Sawczuk Marek: Institute of Physical Culture Sciences, University of Szczecin, 70-453 Szczecin, Poland

IJERPH, 2022, vol. 20, issue 1, 1-8

Abstract: Understanding the risk factors and etiology of ACL ruptures (anterior cruciate ligament) is crucial due to the injury’s high occurrence, significant financial cost to the healthcare sector, and clinical consequences. In this study, we investigated the hypothesis that rs11784270 A/C and rs6577958 C/T SNPs (single gene polymorphism) within COL22A1 are associated with ACL ruptures (ACLR) in Polish soccer players. Methods: 228 athletes with ACLR (157 male, age 26 ± 4, 71 female, age 26 ± 6) and 202 control athletes (117 male, age 26 ± 6, 85 female, age 29 ± 2) engaged in the study. The buccal cell swabs were genotyped using TaqMan ® pre-designed SNP genotyping assays, following the manufacturer’s recommendations. The R program and SNPassoc package were used to determine the genotype and allele frequency distributions under the various inheritance models (co-dominant, dominant, recessive, and over-dominant). Further, p -values of <0.05 were considered statistically significant. We found no association between the analyzed polymorphisms and the risk of non-contact ACL ruptures in any of the studied models. Although the genetic variants investigated in this study were not associated with the risk of non-contact ACL ruptures, we assumed that the COL22A1 gene remains a candidate for further investigations in musculoskeletal injuries.

Keywords: COL22A1 gene; injury; ACL; athletes (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/20/1/515/pdf (application/pdf)
https://www.mdpi.com/1660-4601/20/1/515/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:20:y:2022:i:1:p:515-:d:1018007

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().