Red Cell Distribution Width as a Predictive Factor of Celiac Disease in Middle and Late Adulthood and Its Potential Utility as Celiac Disease Screening Criterion

Julia María Cabo del Riego (), María Jesús Núñez-Iglesias (), José Paz Carreira, Andrés Blanco Hortas, Tamara Álvarez Fernández, Silvia Novío Mallón, Sofía Zaera and Manuel Freire-Garabal Núñez
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Julia María Cabo del Riego: Clinical Analysis Laboratory, Department of Immunology, Lucus Augusti University Hospital, 27003 Lugo, Spain
María Jesús Núñez-Iglesias: SNLLaboratory, School of Medicine and Dentistry, University of Santiago de Compostela, 15782 A Coruña, Spain
José Paz Carreira: Department of Hematology, Oncology Center of Galicia, 15009 A Coruña, Spain
Andrés Blanco Hortas: Health Research Institute Foundation (FIDIS) of Santiago de Compostela, Lucus Augusti University Hospital, 15706 Santiago de Compostela, Spain
Tamara Álvarez Fernández: Clinical Analysis Laboratory, Department of Immunology, Lucus Augusti University Hospital, 27003 Lugo, Spain
Silvia Novío Mallón: SNLLaboratory, School of Medicine and Dentistry, University of Santiago de Compostela, 15782 A Coruña, Spain
Sofía Zaera: Clinical Analysis Laboratory, Department of Immunology, Lucus Augusti University Hospital, 27003 Lugo, Spain
Manuel Freire-Garabal Núñez: SNLLaboratory, School of Medicine and Dentistry, University of Santiago de Compostela, 15782 A Coruña, Spain

IJERPH, 2022, vol. 20, issue 1, 1-14

Abstract: Red cell distribution width (RDW) could be of interest by its potential use in the assessment of celiac disorder (CD). The main objective of this study was to evaluate the case positive rate of CD and the utility of red cell distribution width (RDW) in the CD diagnosis. This prospective study included 9.066 middle adult (≥45 years old) and elderly patients (≥60 years old) from 2012 to 2021. CD diagnosis was performed by CD antibody tests (serology and Human Leucocyte Antigen genotype (HLA)) and biopsy. Gastrointestinal and extra-intestinal manifestations as well as hematological and biochemical parameters were analyzed. CD diagnoses were confirmed in 101 patients (median (IQR) age = 62 (52.3–73); 68.32% women) by serologic tests (100%) and intestinal biopsy (88.12%), showing mainly marked or complete atrophy (76.24%, MARSH 3a–c). Anemia was the most commonly presenting extra-intestinal manifestation (28.57%). Among 8975 individuals without CD, 168 age and sex matched were included. By comparison of CD and no CD individuals, we observed that high >14.3% RDW was exhibited by 58.40% and 35.2% individuals with CD and without CD, respectively. Furthermore, high RDW is associated with CD and grade III atrophy. We suggest that RDW could be used as a CD screening criterion.

Keywords: red blood width; celiac disease; onset; diagnosis; adult; elderly (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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