Impaired Speckle-Tracking-Derived Left Ventricular Longitudinal Strain Is Associated with Transposition of Great Arteries in Neonates: A Single-Center Study

Daniela Toma, Dorottya Gabor-Miklosi, Andreea Cerghit-Paler, Carmen Corina Șuteu, Marius-Catalin Cosma, Claudiu Mărginean, Mihaela Iancu () and Liliana Gozar
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Daniela Toma: Emergency Institute of Cardiovascular Diseases and Transplantation, 540139 Târgu-Mureș, Romania
Dorottya Gabor-Miklosi: Emergency Institute of Cardiovascular Diseases and Transplantation, 540139 Târgu-Mureș, Romania
Andreea Cerghit-Paler: Emergency Institute of Cardiovascular Diseases and Transplantation, 540139 Târgu-Mureș, Romania
Carmen Corina Șuteu: Emergency Institute of Cardiovascular Diseases and Transplantation, 540139 Târgu-Mureș, Romania
Marius-Catalin Cosma: Emergency Institute of Cardiovascular Diseases and Transplantation, 540139 Târgu-Mureș, Romania
Claudiu Mărginean: Department of Obstetrics and Gynecology,”George Emil Palade” University of Medicine, Pharmacy, Science, and Technology of Târgu-Mureș, 540139 Târgu-Mureș, Romania
Mihaela Iancu: Department of Medical Informatics and Biostatistics, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca, 400349 Cluj-Napoca, Romania
Liliana Gozar: Emergency Institute of Cardiovascular Diseases and Transplantation, 540139 Târgu-Mureș, Romania

IJERPH, 2022, vol. 20, issue 1, 1-11

Abstract: The transposition of great arteries (TGA) is one of the most frequent and severe congenital heart diseases. After newborn stabilization and while pending surgical correction, echocardiographic monitoring with a careful evaluation of left ventricle (LV) performance is warranted. In this study, our objectives were (i) to compare myocardial function, assessed via speckle-tracking echocardiography, between neonates with TGA and neonates without TGA and (ii) to identify a strain parameter with a good discriminatory ability for TGA. We conducted a retrospective, single-center study. A total of 90 neonates were examined, of whom 66 were included (16 comprised the TGA group and 50 comprised the control group). The results of a bivariate analysis showed that classic echocardiography parameters displayed no significant differences between the two studied groups ( p = 0.785 for EF, p = 0.286 for MAPSE and p = 0.315 for TAPSE). We found a statistically significant difference between the two groups for the mean values of the LVpGLS parameter (adjusted p = 0.0047), with impaired LV myocardium function being observed in the TGA group after adjusting for other covariates. Regarding segmental strain, the mean medial and apical inter-ventricular septum strain values were found to be significantly lower in the neonates with TGA than in the controls (95% CI for difference in means: [−6.45, −0.65], [−8.56, −1.97]). The results of an ROC analysis showed that LVpGLS had a significant ability to differentiate between neonates with TGA and controls (AUC = 0.712, 95% CI: [0.52, 0.903], p = 0.011). In conclusion, LVpGLS is a parameter with a significant discriminatory ability for LV dysfunction, and it is useful in the evaluation of ventricular myocardial function in newborns with TGA.

Keywords: transposition of great arteries; speckle tracking; echocardiography; myocardial strain; congenital heart disease; pediatric cardiology (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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