Bioimpedance-Derived Membrane Capacitance: Clinically Relevant Sources of Variability, Precision, and Reliability

Valene Garr Barry (), Jasmine L. Chiang, Kaylan G. Bowman, Kristina D. Johnson and Barbara A. Gower
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Valene Garr Barry: Department of Obstetrics and Gynecology, Division of Clinical Research, School of Medicine in St. Louis, Washington University, St. Louis, MO 63108, USA
Jasmine L. Chiang: Department of Obstetrics and Gynecology, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
Kaylan G. Bowman: Department of Nutrition Sciences, School of Health Professions, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
Kristina D. Johnson: Department of Nutrition Sciences, School of Health Professions, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
Barbara A. Gower: Department of Nutrition Sciences, School of Health Professions, The University of Alabama at Birmingham, Birmingham, AL 35294, USA

IJERPH, 2022, vol. 20, issue 1, 1-13

Abstract: Membrane capacitance (C M ), a bioimpedance-derived measure of cell membrane health, has been suggested as an indicator of health status. However, there are few published data to support its use in clinical settings. Hence, this study evaluated clinically relevant sources of variation, precision, and reliability of C M measurements. This longitudinal study included 60 premenopausal women. Sources of variability (e.g., demographics, body composition, serum measures, diet) were identified by stepwise regression. Precision and reliability were assessed by the coefficient of variation (CV), intraclass correlation coefficients (ICC), and technical error of the measurement (TEM) for intra-day (30 min apart) and inter-day measurements (7–14 days apart). Body composition, temperature, and metabolic activity were identified as sources of variability. C M measurements had high precision (CV = 0.42%) and high reliability for intra-day (ICC = 0.996) and inter-day (ICC = 0.959) measurements, independent of menstrual cycle and obesity status. Our results showed that C M measurements are sensitive to clinical factors and have high precision and reliability. The results of this study suggest that C M is sufficiently reliable for health status monitoring in conditions with variation in body composition, metabolic activity, or body temperature among premenopausal women.

Keywords: membrane capacitance; bioimpedance; reliability; women; health status (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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