One-Hour Post-Load Plasma Glucose and Altered Glucometabolic Profile in Youths with Overweight or Obesity

Procolo Di Bonito, Giuliana Valerio, Maria Rosaria Licenziati, Domenico Corica, Malgorzata Wasniewska, Anna Di Sessa, Emanuele Miraglia del Giudice, Anita Morandi, Claudio Maffeis, Enza Mozzillo, Valeria Calcaterra, Francesca Franco, Giulio Maltoni and Maria Felicia Faienza ()
Additional contact information
Procolo Di Bonito: Department of Internal Medicine, “S. Maria delle Grazie” Hospital, 80078 Pozzuoli, Italy
Giuliana Valerio: Department of Movement Sciences and Wellbeing, University of Napoli “Parthenope”, 80133 Napoli, Italy
Maria Rosaria Licenziati: Neuro-Endocrine Diseases and Obesity Unit, Department of Neurosciences, Santobono-Pausilipon Children’s Hospital, 80139 Napoli, Italy
Domenico Corica: Department of Human Pathology in Adulthood and Childhood, University of Messina, 98125 Messina, Italy
Malgorzata Wasniewska: Department of Human Pathology in Adulthood and Childhood, University of Messina, 98125 Messina, Italy
Anna Di Sessa: Department of Woman, Child and of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Napoli, Italy
Emanuele Miraglia del Giudice: Department of Woman, Child and of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Napoli, Italy
Anita Morandi: Department of Surgery, Dentistry, Pediatrics and Gynecology, Section of Pediatric Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, 37126 Verona, Italy
Claudio Maffeis: Department of Surgery, Dentistry, Pediatrics and Gynecology, Section of Pediatric Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, 37126 Verona, Italy
Enza Mozzillo: Section of Pediatrics, Department of Translational Medical Science, Regional Center of Pediatric Diabetes, University of Naples “Federico II”, 80131 Napoli, Italy
Valeria Calcaterra: Pediatric Department, “V. Buzzi” Children’s Hospital, 20154 Milano, Italy
Francesca Franco: Pediatric Department, Azienda Sanitaria Universitaria Friuli Centrale, Hospital of Udine, 33100 Udine, Italy
Giulio Maltoni: Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy
Maria Felicia Faienza: Department of Precision and Regenerative Medicine and Ionian Area, University of Bari “Aldo Moro”, 70121 Bari, Italy

IJERPH, 2023, vol. 20, issue 11, 1-11

Abstract: In youths, two cut-offs (133 and 155 mg/dL) have been proposed to identify high glucose levels at the 1 h (G 60 ) mark during an oral glucose tolerance test (OGTT). We evaluated which cut-off was more closely associated with isolated impaired glucose tolerance (IGT) and cardiometabolic risk (CMR) in 1199 youth with overweight/obesity (OW/OB) and normal fasting glucose and/or HbA1c. The disposition index (DI) was available in 724 youths. The sample was divided by two cut-offs of G 60 : <133 mg/dL (n = 853) and ≥133 mg/dL (n = 346), or G 60 < 155 mg/dL (n = 1050) and ≥155 mg/dL (n = 149). Independent of the cut-off, youths with high levels of G 60 showed higher levels of G 120 , insulin resistance (IR), triglycerides to HDL ratio (TG/HDL), alanine aminotransferase (ALT), and lower insulin sensitivity (IS) and DI than youths with lower levels of G 60 . The percentage of youths showing IGT, IR, low IS, high TG/HDL ratio, high ALT, and low DI was 50% higher in the G 60 ≥ 133 mg/dL group than in the G 60 ≥ 155 mg/dL one. In youths with OW/OB and IGT, a cut-off of G 60 ≥ 133 mg/dL is more useful than G 60 ≥ 155 mg/dL to identify those at high risk of IGT and altered CMR profile.

Keywords: one-hour post-load plasma glucose; obese; youth; glucometabolic; impaired glucose tolerance (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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