The ORIGINS Project Biobank: A Collaborative Bio Resource for Investigating the Developmental Origins of Health and Disease

Nina D’Vaz, Courtney Kidd, Sarah Miller, Minda Amin, Jacqueline A. Davis, Zenobia Talati, Desiree T. Silva and Susan L. Prescott
Additional contact information
Nina D’Vaz: Telethon Kids Institute, North Entrance Perth Children’s Hospital, 15 Hospital Ave, Nedlands, WA 6009, Australia
Courtney Kidd: Telethon Kids Institute, North Entrance Perth Children’s Hospital, 15 Hospital Ave, Nedlands, WA 6009, Australia
Sarah Miller: Telethon Kids Institute, North Entrance Perth Children’s Hospital, 15 Hospital Ave, Nedlands, WA 6009, Australia
Minda Amin: Telethon Kids Institute, North Entrance Perth Children’s Hospital, 15 Hospital Ave, Nedlands, WA 6009, Australia
Jacqueline A. Davis: Telethon Kids Institute, North Entrance Perth Children’s Hospital, 15 Hospital Ave, Nedlands, WA 6009, Australia
Zenobia Talati: Telethon Kids Institute, North Entrance Perth Children’s Hospital, 15 Hospital Ave, Nedlands, WA 6009, Australia
Desiree T. Silva: Telethon Kids Institute, North Entrance Perth Children’s Hospital, 15 Hospital Ave, Nedlands, WA 6009, Australia
Susan L. Prescott: Telethon Kids Institute, North Entrance Perth Children’s Hospital, 15 Hospital Ave, Nedlands, WA 6009, Australia

IJERPH, 2023, vol. 20, issue 13, 1-17

Abstract: Early onset Non-Communicable Diseases (NCDs), including obesity, allergies, and mental ill-health in childhood, present a serious and increasing threat to lifelong health and longevity. The ORGINS Project (ORIGINS) addresses the urgent need for multidisciplinary efforts to understand the detrimental multisystem impacts of modern environments using well-curated large-scale longitudinal biological sample collections. ORGINS is a prospective community birth cohort aiming to enrol 10,000 pregnant people and follow each family until the children reach 5 years of age. A key objective is to generate a comprehensive biorepository on a sub-group of 4000 families invited to contribute blood, saliva, buccal cells, urine, stool, hair, house dust, cord blood, placenta, amniotic fluid, meconium, breastmilk, and colostrum over eight timepoints spanning the antenatal period and early childhood. Uniquely, ORIGINS includes a series of nested sub-projects, including interventions and clinical trials addressing different aspects of health. While this adds complexity as the project expands, it provides the opportunity for comparative studies. This research design promotes a multidisciplinary, multisystem approach to biological sample collection, analysis, and data sharing to ensure more integrated perspectives and solutions. This paper details the evolving protocol of our collaborative biobanking concept. Further, we outline our future visions for local, national, and ultimately international, comparative, and collaborative opportunities to advance our understanding of early onset NCDs and the opportunities to improve health outcomes for future generations.

Keywords: ORIGINS; biobank; biorepository; birth cohort; non-communicable disease; microbiome; DOHaD (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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