Environmental Planning and Non-Communicable Diseases: A Systematic Review on the Role of the Metabolomic Profile

Natália Cristina de Oliveira (), Pedro Balikian Júnior, Arnaldo Tenório da Cunha Júnior, Edson de Souza Bento, Josealdo Tonholo, Thiago Aquino, Filipe Antonio de Barros Sousa, Gustavo Gomes de Araujo and Maurício Lamano Ferreira
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Natália Cristina de Oliveira: Department of Nursing and Health, Guarulhos University, Central Campus, Guarulhos 07023-070, SP, Brazil
Pedro Balikian Júnior: Institute of Physical Education and Sport (IEFE), Federal University of Alagoas, Campus AC Simões, Maceió 57072-900, AL, Brazil
Arnaldo Tenório da Cunha Júnior: Kineanthropometry, Physical Activity and Health Promotion Laboratory (LACAPS), Physical Education Department, Federal University of Alagoas, Campus Arapiraca, Arapiraca 57309-005, AL, Brazil
Edson de Souza Bento: Institute of Chemistry and Biotechnology (IQB), Federal University of Alagoas, Campus AC Simões, Maceió 57072-900, AL, Brazil
Josealdo Tonholo: Institute of Chemistry and Biotechnology (IQB), Federal University of Alagoas, Campus AC Simões, Maceió 57072-900, AL, Brazil
Thiago Aquino: Institute of Chemistry and Biotechnology (IQB), Federal University of Alagoas, Campus AC Simões, Maceió 57072-900, AL, Brazil
Filipe Antonio de Barros Sousa: Institute of Physical Education and Sport (IEFE), Federal University of Alagoas, Campus AC Simões, Maceió 57072-900, AL, Brazil
Gustavo Gomes de Araujo: Institute of Physical Education and Sport (IEFE), Federal University of Alagoas, Campus AC Simões, Maceió 57072-900, AL, Brazil
Maurício Lamano Ferreira: Department of Geoenvironmental Analysis, Guarulhos University, Central Campus, Guarulhos 07023-070, SP, Brazil

IJERPH, 2023, vol. 20, issue 14, 1-15

Abstract: Non-communicable diseases (NCDs) are the major cause of death worldwide and have economic, psychological, and social impacts. Air pollution is the second, contributing to NCDs-related deaths. Metabolomics are a useful diagnostic and prognostic tool for NCDs, as they allow the identification of biomarkers linked to emerging pathologic processes. The aim of the present study was to review the scientific literature on the application of metabolomics profiling in NCDs and to discuss environmental planning actions to assist healthcare systems and public managers based on early metabolic diagnosis. The search was conducted following PRISMA guidelines using Web of Science, Scopus, and PubMed databases with the following MeSH terms: “metabolomics” AND “noncommunicable diseases” AND “air pollution”. Twenty-nine studies were eligible. Eleven involved NCDs prevention, eight addressed diabetes mellitus, insulin resistance, systemic arterial hypertension, or metabolic syndrome. Six studies focused on obesity, two evaluated nonalcoholic fatty liver disease, two studied cancer, and none addressed chronic respiratory diseases. The studies provided insights into the biological pathways associated with NCDs. Understanding the cost of delivering care where there will be a critical increase in NCDs prevalence is crucial to achieving universal health coverage and improving population health by allocating environmental planning and treatment resources.

Keywords: metabolomics; environmental hazards; non-communicable diseases; environmental planning (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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