Boldine Alters Serum Lipidomic Signatures after Acute Spinal Cord Transection in Male Mice

Zachary A. Graham (), Jacob A. Siedlik, Carlos A. Toro, Lauren Harlow and Christopher P. Cardozo
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Zachary A. Graham: Research Service, Birmingham VA Health Care System, Birmingham, AL 35233, USA
Jacob A. Siedlik: Department of Exercise Science and Pre-Health Professions, Creighton University, Omaha, NE 68178, USA
Carlos A. Toro: Spinal Cord Damage Research Center, Bronx, NY 10468, USA
Lauren Harlow: Spinal Cord Damage Research Center, Bronx, NY 10468, USA
Christopher P. Cardozo: Spinal Cord Damage Research Center, Bronx, NY 10468, USA

IJERPH, 2023, vol. 20, issue 16, 1-14

Abstract: Traumatic spinal cord injury (SCI) results in wide-ranging cellular and systemic dysfunction in the acute and chronic time frames after the injury. Chronic SCI has well-described secondary medical consequences while acute SCI has unique metabolic challenges as a result of physical trauma, in-patient recovery and other post-operative outcomes. Here, we used high resolution mass spectrometry approaches to describe the circulating lipidomic and metabolomic signatures using blood serum from mice 7 d after a complete SCI. Additionally, we probed whether the aporphine alkaloid, boldine, was able to prevent SCI-induced changes observed using these ‘omics platforms’. We found that SCI resulted in large-scale changes to the circulating lipidome but minimal changes in the metabolome, with boldine able to reverse or attenuate SCI-induced changes in the abundance of 50 lipids. Multiomic integration using xMWAS demonstrated unique network structures and community memberships across the groups.

Keywords: spinal cord injury; lipidomics; boldine (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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