A Review on Inflammasomes and Immune Checkpoints in Pre-Eclampsia Complicated with Tuberculosis and Human Immune Deficiency Virus

Wendy N. Phoswa (), Olive P. Khaliq and Simeon Eche
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Wendy N. Phoswa: Department of Life and Consumer Sciences, Science Campus, University of South Africa (UNISA), Private Bag X 6, Florida, Roodepoort 1710, South Africa
Olive P. Khaliq: Department of Paediatrics and Child Health, University of the Free State, Bloemfontein 9300, South Africa
Simeon Eche: School of Medicine, Yale University, 333 Cedar Street, New Haven, CO 06510, USA

IJERPH, 2023, vol. 20, issue 17, 1-15

Abstract: The current review evaluates how inflammasomes and immune checkpoints are regulated in pre-eclampsia (PE) associated with tuberculosis (TB) and Human Immune Deficiency Virus (HIV). Studies indicate that inflammasomes such as (NRLP3, NEK7, and AIM2) and immune checkpoints such as (CLT4, PD-1, TIM3, and LAG-3) are dysregulated in TB- and HIV-infected individuals, and also in pre-eclamptic pregnancies, which explains why pregnant women who are either infected with TB or HIV have an increased risk of developing PE. Evidence suggests that inhibition of inflammasomes and immune checkpoints may assist in the development of novel anti-inflammatory drugs for the prevention and management of PE in patients with or without TB and HIV infection.

Keywords: inflammasomes; immune check points; inflammation; tuberculosis; HIV; pre-eclampsia (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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