Factors Associated with Long COVID-19 in a French Multicentric Prospective Cohort Study

Nagham Khanafer (), Laetitia Henaff, Sabrina Bennia, Anne Termoz, Roland Chapurlat, Vanessa Escuret, Mathilde Proriol, Florence Duvert, Camille Mena, Catherine Planckaert, Nadège Trehet-Mandez, Mitra Saadatian-Elahi and Philippe Vanhems
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Nagham Khanafer: Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, CNRS UMR5308, ENS de Lyon, Lyon 1 University, CEDEX 07, 69364 Lyon, France
Laetitia Henaff: Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, CNRS UMR5308, ENS de Lyon, Lyon 1 University, CEDEX 07, 69364 Lyon, France
Sabrina Bennia: Department of Hygiene, Epidemiology, and Prevention, Edouard Herriot Hospital, Hospices Civils de Lyon, 69003 Lyon, France
Anne Termoz: Service Recherche et Epidémiologie Cliniques, Hospices Civils de Lyon, Pôle Santé Publique, 69003 Lyon, France
Roland Chapurlat: Department of Rheumatology, Edouard Herriot University Hospital, Hospices Civils de Lyon, 69003 Lyon, France
Vanessa Escuret: Institut des Agents Infectieux, Hospices Civils de Lyon, 69317 Lyon, France
Mathilde Proriol: Department of Rheumatology, Edouard Herriot University Hospital, Hospices Civils de Lyon, 69003 Lyon, France
Florence Duvert: INSERM UMR 1033, University of Lyon, 69003 Lyon, France
Camille Mena: INSERM UMR 1033, University of Lyon, 69003 Lyon, France
Catherine Planckaert: INSERM UMR 1033, University of Lyon, 69003 Lyon, France
Nadège Trehet-Mandez: INSERM UMR 1033, University of Lyon, 69003 Lyon, France
Mitra Saadatian-Elahi: Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, CNRS UMR5308, ENS de Lyon, Lyon 1 University, CEDEX 07, 69364 Lyon, France
Philippe Vanhems: Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, CNRS UMR5308, ENS de Lyon, Lyon 1 University, CEDEX 07, 69364 Lyon, France

IJERPH, 2023, vol. 20, issue 17, 1-12

Abstract: (1) Background: A substantial proportion of COVID-19 patients continue to experience long-lasting effects that hamper their quality of life. The objectives of this study were (1) to report the prevalence of persistent clinical symptoms 6–12 months after the onset of COVID-19 and (2) to identify potential factors at admission associated with the occurrence of long COVID. (2) Methods: A prospective study was conducted among COVID-19 adult patients, hospitalized in four French university hospitals. Patients were invited to two ambulatory follow-up medical visits, 6–8 months (visit #1) and one year (visit #2) after the onset of their COVID-19. A multivariate logistic regression was performed to assess factors associated with long COVID. (3) Results: In total, 189 patients participated in this study (mean age of 63.4 years). BMI > 30 kg/m 2 (aOR 3.52), AST levels between 31 and 42 U/L (aOR 8.68), and AST levels > 42 U/L (aOR 3.69) were associated with persistent clinical symptoms at visit #1. Anosmia (aOR 13.34), AST levels between 31 and 42 U/L (aOR 10.27), stay in ICU (aOR 5.43), pain (aOR 4.31), and longer time before hospitalization (aOR 1.14) were significantly associated with persistent clinical symptoms at visit #2. Patients with ageusia (aOR 0.17) had a lower risk of long COVID. (4) Conclusions: This study showed that some patients experienced persistent clinical symptoms one year after COVID-19 onset that were associated with some determinants at the acute phase/stage.

Keywords: COVID-19 pandemic; SARS-CoV-2; long COVID-19; post-COVID-19 syndrome; risk factors (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
References: View complete reference list from CitEc
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