Maternal, Fetal and Neonatal Outcomes Related to Recreational Cannabis Use during Pregnancy: Analysis of a Real-World Clinical Data Warehouse between 2010 and 2019

Emilie Bouquet (), Pascal Blouin, Marie-Christine Pérault-Pochat, Caroline Carlier-Guérin, Frédéric Millot, Jean-Baptiste Ricco, Joe De Keizer, Stéphanie Pain and Farid Guétarni
Additional contact information
Emilie Bouquet: Addictovigilance Center, Department of Clinical Pharmacology, Poitiers University Hospital, 86000 Poitiers, France
Pascal Blouin: Department of Clinical Research and Innovation, Poitiers University Hospital, 86000 Poitiers, France
Marie-Christine Pérault-Pochat: Addictovigilance Center, Department of Clinical Pharmacology, Poitiers University Hospital, 86000 Poitiers, France
Caroline Carlier-Guérin: Department of Obstetrics and Gynecology, Poitiers University Hospital, 86000 Poitiers, France
Frédéric Millot: Department of Pediatrics, Poitiers University Hospital, 86000 Poitiers, France
Jean-Baptiste Ricco: Department of Clinical Research and Innovation, Poitiers University Hospital, 86000 Poitiers, France
Joe De Keizer: Clinical Investigation Center CIC1402, INSERM, Poitiers University Hospital, University of Poitiers, 86000 Poitiers, France
Stéphanie Pain: Addictovigilance Center, Department of Clinical Pharmacology, Poitiers University Hospital, 86000 Poitiers, France
Farid Guétarni: Department of Clinical Research and Innovation, Poitiers University Hospital, 86000 Poitiers, France

IJERPH, 2023, vol. 20, issue 17, 1-14

Abstract: Background: Cannabis is the main illicit psychoactive substance used in French childbearing women and very few data are available about adverse events (AEs) related to its use during pregnancy. The aim of this study was to evaluate the association between recreational cannabis use during pregnancy and adverse outcomes from a real-world clinical data warehouse. Methods: Data from the Poitiers University Hospital warehouse were analyzed between 1 January 2010 and 31 December 2019. Logistic regression models were used to evaluate associations between outcomes in three prenatal user groups: cannabis alone ± tobacco (C ± T) ( n = 123), tobacco alone (T) ( n = 191) and controls (CTRL) ( n = 355). Results: Pregnant women in the C ± T group were younger (mean age: 25.5 ± 5.7 years), had lower pre-pregnancy body mass index (22.8 ± 5.5 kg/m 2 ), more psychiatric history (17.5%) and were more likely to benefit from universal free health-care coverage (18.2%) than those in the T and CTRL groups. Cannabis use increases the occurrence of voluntary interruption of pregnancy, at least one AE during pregnancy, at least one neonatal AE, the composite adverse pregnancy outcome over 28, prematurity and small for gestational age. Conclusion: Given the trivialization of recreational cannabis use during pregnancy, there is an urgent need to communicate on AEs of cannabis use during pregnancy.

Keywords: recreational cannabis; adverse events; pregnancy; perinatal (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/20/17/6686/pdf (application/pdf)
https://www.mdpi.com/1660-4601/20/17/6686/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:20:y:2023:i:17:p:6686-:d:1229393

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().