Muscular Adaptations to Concurrent Resistance Training and High-Intensity Interval Training in Adults with Type 2 Diabetes: A Pilot Study

Giorgio Orlando (), Jamie Pugh, Steve Faulkner, Stefano Balducci, Massimo Sacchetti, Giuseppe Pugliese, Ilenia Bazzucchi, Jonida Haxhi, Eduardo Martinez-Valdes, Deborah Falla, Konstantinos Manolopoulos and Myra A. Nimmo
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Giorgio Orlando: Research Centre for Musculoskeletal Science & Sports Medicine, Department of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester M15GD, UK
Jamie Pugh: College of Life and Environmental Sciences, University of Birmingham, Birmingham B152TT, UK
Steve Faulkner: Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE113TU, UK
Stefano Balducci: Diabetes Unit, Department of Clinical and Molecular Medicine, “La Sapienza” University, Sant’ Andrea University Hospital, 00185 Rome, Italy
Massimo Sacchetti: Department of Human Movement and Sport Sciences, University of Rome “Foro Italico”, 00135 Rome, Italy
Giuseppe Pugliese: Diabetes Unit, Department of Clinical and Molecular Medicine, “La Sapienza” University, Sant’ Andrea University Hospital, 00185 Rome, Italy
Ilenia Bazzucchi: Department of Human Movement and Sport Sciences, University of Rome “Foro Italico”, 00135 Rome, Italy
Jonida Haxhi: Diabetes Unit, Department of Clinical and Molecular Medicine, “La Sapienza” University, Sant’ Andrea University Hospital, 00185 Rome, Italy
Eduardo Martinez-Valdes: School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham B152TT, UK
Deborah Falla: School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham B152TT, UK
Konstantinos Manolopoulos: Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B152TT, UK
Myra A. Nimmo: College of Life and Environmental Sciences, University of Birmingham, Birmingham B152TT, UK

IJERPH, 2023, vol. 20, issue 18, 1-11

Abstract: This pilot study aimed to compare the effects of eight weeks of concurrent resistance training (RT) and high-intensity interval training (HIIT) vs. RT alone on muscle performance, mass and quality in adults with type 2 diabetes (T2DM). Twelve T2DM adults were randomly allocated to the RT + HIIT (n = 5) or RT (n = 7) group. Before and after training, maximal oxygen uptake (VO 2max ), muscle strength and power were evaluated by calorimetry, dynamometry and one-repetition maximum (1RM) test. Quadriceps muscle volume was determined by MRI, and muscle quality was estimated. After RT, VO 2max (+12%), knee muscle power (+20%), quadriceps muscle volume (+5.9%) and quality (leg extension, +65.4%; leg step-up, +223%) and 1RM at leg extension (+66.4%), leg step-up (+267%), lat pulldown (+60.9%) and chest press (+61.2%) significantly increased. The RT + HIIT group improved on VO 2max (+27%), muscle volume (+6%), muscle power (+9%) and 1RM at lat pulldown (+47%). No other differences were detected. Among groups, changes in muscle quality at leg step-up and leg extension and VO 2max were significantly different. The combination of RT and HIIT effectively improves muscle function and size and increases cardiorespiratory fitness in adults with T2DM. However, HIIT combined with RT may interfere with the development of muscle quality.

Keywords: muscle dysfunction; type 2 diabetes; concurrent training; muscle quality and resistance training (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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