The Influence of Short-Term Weather Parameters and Air Pollution on Adolescent Airway Inflammation

Ashtyn Tracey Areal, Nidhi Singh, Qi Zhao, Dietrich Berdel, Sibylle Koletzko, Andrea von Berg, Monika Gappa, Joachim Heinrich, Marie Standl, Michael J. Abramson and Tamara Schikowski ()
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Ashtyn Tracey Areal: IUF—Leibniz Research Institute for Environmental Medicine, 40225 Düsseldorf, Germany
Nidhi Singh: IUF—Leibniz Research Institute for Environmental Medicine, 40225 Düsseldorf, Germany
Qi Zhao: IUF—Leibniz Research Institute for Environmental Medicine, 40225 Düsseldorf, Germany
Dietrich Berdel: Department of Pediatrics, Research Institute, Marien-Hospital Wesel, 46483 Wesel, Germany
Sibylle Koletzko: Department of Pediatrics, Dr. von Hauner Children’s Hospital Munich, University Hospital, LMU Munich, 80539 Munich, Germany
Andrea von Berg: Department of Pediatrics, Research Institute, Marien-Hospital Wesel, 46483 Wesel, Germany
Monika Gappa: Department of Paediatrics, Evangelisches Krankenhaus, 40217 Düsseldorf, Germany
Joachim Heinrich: Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, 80539 Munich, Germany
Marie Standl: German Center for Lung Research (DZL), 35392 Gießen, Germany
Michael J. Abramson: School of Public Health & Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia
Tamara Schikowski: IUF—Leibniz Research Institute for Environmental Medicine, 40225 Düsseldorf, Germany

IJERPH, 2023, vol. 20, issue 19, 1-11

Abstract: Fraction of exhaled Nitric Oxide (FeNO) is a marker of airway inflammation. We examined the main effects and interactions of relative humidity (RH) and air pollution on adolescents’ FeNO. Two thousand and forty-two participants from the 15-year follow-up of the German GINIplus and LISA birth cohorts were included. Daily meteorological (maximum [Tmax], minimum [Tmin] and mean [Tmean] temperatures and RH) and air pollution [Ozone (O 3 ), nitrogen dioxide (NO 2 ) and particulate matter < 2.5 µm (PM 2.5 )] were assessed. Linear models were fitted with Ln(FeNO) as the outcome. Increases in FeNO indicate an increase in lung inflammation. Increased FeNO was associated with an increase in temperature, PM 2.5 , O 3 and NO 2 . A 5% increase in RH was associated with a decrease in FeNO. Interactions between RH and high ( p = 0.007) and medium ( p = 0.050) NO 2 were associated with increases in FeNO; while interactions between RH and high ( p = 0.042) and medium ( p = 0.040) O 3 were associated with decreases in FeNO. Adverse effects were present for male participants, participants with low SES, participants with chronic respiratory disease, and participants from Wesel. Short-term weather and air pollution have an effect on lung inflammation in German adolescents. Future research should focus on further assessing the short-term effect of multiple exposures on lung inflammation in adolescents.

Keywords: relative humidity; air pollution; environmental epidemiology; fraction of exhaled nitric oxide; adolescent; cohort studies (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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