Depressed Mood as a Significant Risk Factor for Gynecological Cancer Aggravation

Seon-Mi Lee, Jae-Yun Song (), Aeran Seol, Sanghoon Lee, Hyun-Woong Cho, Kyung-Jin Min, Jin-Hwa Hong, Jae-Kwan Lee and Nak-Woo Lee
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Seon-Mi Lee: Department of Obstetrics and Gynecology, Korea University College of Medicine, Korea University Anam Hospital, Seoul 02841, Republic of Korea
Jae-Yun Song: Department of Obstetrics and Gynecology, Korea University College of Medicine, Korea University Anam Hospital, Seoul 02841, Republic of Korea
Aeran Seol: Department of Obstetrics and Gynecology, Korea University College of Medicine, Korea University Anam Hospital, Seoul 02841, Republic of Korea
Sanghoon Lee: Department of Obstetrics and Gynecology, Korea University College of Medicine, Korea University Anam Hospital, Seoul 02841, Republic of Korea
Hyun-Woong Cho: Department of Obstetrics and Gynecology, Korea University College of Medicine, Korea University Guro Hospital, Seoul 08308, Republic of Korea
Kyung-Jin Min: Department of Obstetrics and Gynecology, Korea University College of Medicine, Korea University Ansan Hospital, Ansan 15355, Republic of Korea
Jin-Hwa Hong: Department of Obstetrics and Gynecology, Korea University College of Medicine, Korea University Guro Hospital, Seoul 08308, Republic of Korea
Jae-Kwan Lee: Department of Obstetrics and Gynecology, Korea University College of Medicine, Korea University Guro Hospital, Seoul 08308, Republic of Korea
Nak-Woo Lee: Department of Obstetrics and Gynecology, Korea University College of Medicine, Korea University Ansan Hospital, Ansan 15355, Republic of Korea

IJERPH, 2023, vol. 20, issue 19, 1-10

Abstract: Background: The aim of this study was to evaluate the relationship between depressed mood and gynecological cancer outcomes, identifying risk factors for cancer aggravation. Methods: This study was a retrospective analysis of gynecological cancer patients (January 2020–August 2022) at Korea University Anam Hospital using Patient Health Questionnaire-9 (PHQ-9). Patients were classified into non-depressed mood (NDM)- and depressed mood (DM)-based scores. Statistical analysis was performed using Student’s t -test, chi-square test, Fisher’s exact test, Kaplan–Meier analysis, and Cox regression analyzing using SPSS. Results: Of the 217 participants, the NDM group comprised 129 patients, and the DM group comprised 88. The two-year disease-free survival (DFS) rates showed significant differences (NDM, 93.6%; DM 86.4%; p = 0.006), but overall survival (OS) did not ( p = 0.128). Patients with stage 3 or higher cancer, undergoing five or more chemotherapies, experiencing post-chemotherapy side effects, and depressed mood had an increased risk of cancer aggravation. Conclusions: Appropriate treatment of depressed mood, as well as adequate treatment for advanced gynecological cancer patients, those with numerous CTx., and those with post-CTx. side effects, may contribute to reducing the risk of cancer aggravation.

Keywords: gynecological cancer; depressed mood; depression; risk factors; cancer aggravation (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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