Factors Associated with the Extent of Clinical Attachment Loss in Periodontitis: A Multicenter Cross-Sectional Study

Gloria Inés Lafaurie, María Alejandra Sabogal, Adolfo Contreras, Diana Marcela Castillo, Diego Fernando Gualtero, Juliette De Avila, Tamy Goretty Trujillo, Andrés Duque, Astrid Giraldo, Silvia Duarte, Sonia Jakeline Gutierrez and Carlos Martín Ardila ()
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Gloria Inés Lafaurie: Unit of Oral Basic Investigation-UIBO, School of Dentistry, El Bosque University, Bogota 11001, Colombia
María Alejandra Sabogal: Unit of Oral Basic Investigation-UIBO, School of Dentistry, El Bosque University, Bogota 11001, Colombia
Adolfo Contreras: Periodontal Medicine Group, Universidad del Valle, Cali 760042, Colombia
Diana Marcela Castillo: Unit of Oral Basic Investigation-UIBO, School of Dentistry, El Bosque University, Bogota 11001, Colombia
Diego Fernando Gualtero: Unit of Oral Basic Investigation-UIBO, School of Dentistry, El Bosque University, Bogota 11001, Colombia
Juliette De Avila: Unit of Oral Basic Investigation-UIBO, School of Dentistry, El Bosque University, Bogota 11001, Colombia
Tamy Goretty Trujillo: Unit of Oral Basic Investigation-UIBO, School of Dentistry, El Bosque University, Bogota 11001, Colombia
Andrés Duque: Research Group in Basic Sciences and Clinical Dentistry, CES University, Medellin 050021, Colombia
Astrid Giraldo: Research Group in Basic Sciences and Clinical Dentistry, CES University, Medellin 050021, Colombia
Silvia Duarte: Dental Research Center-CIO, Pontificia Universidad Javeriana, Bogota 110311, Colombia
Sonia Jakeline Gutierrez: Periodontal Medicine Group, Universidad del Valle, Cali 760042, Colombia
Carlos Martín Ardila: Biomedical Stomatology Research Group, Faculty of Dentistry, Universidad de Antioquia UdeA, Medellin 050010, Colombia

IJERPH, 2023, vol. 20, issue 22, 1-13

Abstract: Periodontitis has significant public health implications, affecting individuals’ overall health, well-being, and quality of life. This study aimed to assess the risk factors associated with the extent of clinical attachment loss (CAL) in a population diagnosed with periodontitis. Six hundred and sixty-seven patients with different degrees of CAL (mild, n = 223; moderate, n = 256; and advanced, n = 188) were enrolled. Socio-demographics, lifestyle, microbiological profiles, specific immune response, obesity, and single-nucleotide polymorphism of the IL1 gene were determined. Unconditional logistic regression models were conducted to determine the factors associated with the extent of CAL. Aging, smoking, microbial factors, plaque index, and IgG2 antibodies against Aggregatibacter actinomycetemcomitans were associated with advanced CAL. IgG2 antibodies against A. actinomycetemcomitans (OR 1.50; CI 95% 1.23–1.81), plaque accumulation (OR 2.69; CI 95% 2.20–3.29), Porphyromonas gingivalis (OR 1.93; CI 95% 1.35–2.76), Tanerella forsythia (OR 1.88; CI 95%1.30–2.70), and current smoking (OR 1.94; CI 95% 1.31–2.87) were associated with advanced CAL. Gene IL polymorphisms, obesity, and stress were not associated with the extent of CAL. Aging, plaque accumulation, smoking, and having antibodies against A. actinomycetemcomitans were the most critical factors associated with advanced CAL. In contrast, obesity, stress, and gene polymorphisms were not associated with the extent of CAL.

Keywords: periodontitis; IgG antibodies; Porphyromonas gingivalis; Aggregatibacter actinomycetemcomitan; smoking; plaque index (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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