Association between METS-IR and Prediabetes or Type 2 Diabetes Mellitus among Elderly Subjects in China: A Large-Scale Population-Based Study

Hui Cheng, Xiao Yu, Yu-Ting Li, Zhihui Jia, Jia-Ji Wang, Yao-Jie Xie, Jose Hernandez, Harry H. X. Wang () and Hua-Feng Wu ()
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Hui Cheng: School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
Xiao Yu: School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
Yu-Ting Li: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China
Zhihui Jia: School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
Jia-Ji Wang: Centre for General Practice, The Seventh Affiliated Hospital, Southern Medical University, Foshan 528244, China
Yao-Jie Xie: School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Kowloon 852, Hong Kong, China
Jose Hernandez: Medicine and Health, EDU Institute of Higher Education, 1320 Kalkara, Malta
Harry H. X. Wang: School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
Hua-Feng Wu: Shishan Community Health Centre of Nanhai, Foshan 528234, China

IJERPH, 2023, vol. 20, issue 2, 1-10

Abstract: The metabolic score for insulin resistance (METS-IR) was recently proposed as a non-insulin-based, novel index for assessing insulin resistance (IR) in the Western population. However, evidence for the link between METS-IR and prediabetes or type 2 diabetes mellitus (T2DM) among the elderly Chinese population was still limited. We aimed to investigate the associations between METS-IR and prediabetes or T2DM based on large-scale, cross-sectional, routine physical examination data. In a total of 18,112 primary care service users, an increased METS-IR was independently associated with a higher prevalence of prediabetes (adjusted odds ratio [aOR] = 1.457, 95% confidence interval [CI]: 1.343 to 1.581, p < 0.001) and T2DM (aOR = 1.804, 95%CI: 1.720 to 1.891, p < 0.001), respectively. The aOR for prediabetes in subjects with the highest quartile of METS-IR was 3.060-fold higher than that in those with the lowest quartile of METS-IR. The aOR for T2DM in subjects with the highest quartile of METS-IR was 6.226-fold higher than that in those with the lowest quartile of METS-IR. Consistent results were obtained in subgroup analyses. Our results suggested that METS-IR was significantly associated with both prediabetes and T2DM. The monitoring of METS-IR may add value to early identification of individuals at risk for glucose metabolism disorders in primary care.

Keywords: METS-IR; prediabetes; T2DM; insulin resistance; cross-sectional study (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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