Titanium Dioxide Nanoparticles Altered the lncRNA Expression Profile in Human Lung Cells

Ying Ma, Jiaqi Shi, Yi Zhang, Zhangjian Chen () and Guang Jia
Additional contact information
Ying Ma: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China
Jiaqi Shi: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China
Yi Zhang: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China
Zhangjian Chen: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China
Guang Jia: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China

IJERPH, 2023, vol. 20, issue 2, 1-11

Abstract: Respiration is considered to be the main occupational or environmental exposure pathway of titanium dioxide nanoparticles (TiO 2 NPs), and the lung is considered to be the target organ of respiratory exposure; however, the mechanism of respiratory toxicity is not fully understood. In this study, the effect of TiO 2 NPs on the expression profile of long non-coding RNA (lncRNA) in bronchial epithelial cells (BEAS-2B) was investigated to understand their potential toxic mechanism. BEAS-2B cells were treated with 100 μg/mL TiO 2 NPs for 48 h, then RNA sequencing was performed to screen the differential lncRNAs compared with the control group, and the enrichment pathways of the differentially expressed lncRNAs were further analyzed using the Kyoto Encyclopedia of Genes and Genomes (KEGG). The results identified a total of 45,769 lncRNAs, and 277 different lncRNAs were screened. KEGG pathway analysis showed that the targeted mRNAs of these different lncRNAs were enriched in the pyrimidine metabolism pathway. This work demonstrates that TiO 2 NPs could alter the lncRNA expression profile in BEAS-2B cells, and epigenetics may play a role in the mechanism of respiratory toxicity induced by TiO 2 NPs.

Keywords: titanium dioxide nanoparticles; respiratory toxicity; BEAS-2B cells; lncRNA; epigenetics (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/20/2/1059/pdf (application/pdf)
https://www.mdpi.com/1660-4601/20/2/1059/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:20:y:2023:i:2:p:1059-:d:1027851

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().