Long-Term Efficacy and Toxicity of Intensity-Modulated Radiotherapy in Bulky Cervical Cancer

Yu Wang, Tan-Tzu Lo, Lily Wang, Shih-Tien Hsu, Sheau-Feng Hwang, Chien-Hsing Lu and Lou Sun ()
Additional contact information
Yu Wang: Department of Gynecology and Obstetrics, Taichung Veterans General Hospital, Taichung 40705, Taiwan
Tan-Tzu Lo: Department of Obstetrics and Gynecology, Madou Sin-Lau Hospital, Tainan 72152, Taiwan
Lily Wang: Department of Radiation Oncology, Taichung Veterans General Hospital, Taichung 40705, Taiwan
Shih-Tien Hsu: Department of Gynecology and Obstetrics, Taichung Veterans General Hospital, Taichung 40705, Taiwan
Sheau-Feng Hwang: Department of Gynecology and Obstetrics, Taichung Veterans General Hospital, Taichung 40705, Taiwan
Chien-Hsing Lu: Department of Gynecology and Obstetrics, Taichung Veterans General Hospital, Taichung 40705, Taiwan
Lou Sun: Department of Gynecology and Obstetrics, Taichung Veterans General Hospital, Taichung 40705, Taiwan

IJERPH, 2023, vol. 20, issue 2, 1-13

Abstract: Treatment of bulky cervical cancer is associated with both high adverse effects and local recurrence rates with traditional box method radiotherapy. Intensity-modulated radiotherapy (IMRT) has been adopted for the treatment of cervical cancer in order to deliver more precise radiation doses to the target region. We retrospectively enrolled a total of 98 patients with cervical cancer ≥4 cm who completed IMRT and point A-based brachytherapy treatment. The median follow-up time of the cohort was 6.84 years, with the 5-year OS and DFS being 66.33% and 75.12%, respectively. In addition, 7.14% of patients experienced local recurrence, 12.24% had distant recurrence, 6.12% had both local and distant recurrence, and 3.06% had persistent disease. In the univariate analysis, lymph node metastasis, higher creatinine levels, higher initial CA-125 and receiving chemotherapy other than cisplatin were all associated with a worse PFS. A tumor size ≥6 cm was associated with an increased incidence of higher grade of acute diarrhea. Grade 3 late radiation proctitis and cystitis developed in 11.22% and 13.27% of patients, respectively. The local recurrence rates and overall efficiencies were not inferior to other studies involving traditional pelvic external beam radiation therapy with concurrent chemotherapy. The safety and efficacy of IMRT for bulky cervical cancer were acceptable.

Keywords: cervical cancer; intensity-modulated radiotherapy; concurrent chemoradiotherapy; cystitis; proctitis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/20/2/1161/pdf (application/pdf)
https://www.mdpi.com/1660-4601/20/2/1161/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:20:y:2023:i:2:p:1161-:d:1029599

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().