The Bidirectional Relationship between Pulmonary Tuberculosis and Lung Cancer

Mădălina Preda, Bogdan Cosmin Tănase, Daniela Luminița Zob, Adelina Silvana Gheorghe, Cristian Virgil Lungulescu, Elena Adriana Dumitrescu, Dana Lucia Stănculeanu (), Loredana Sabina Cornelia Manolescu (), Oana Popescu, Elmira Ibraim and Beatrice Mahler
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Mădălina Preda: Marius Nasta Institute of Pneumology, 050159 Bucharest, Romania
Bogdan Cosmin Tănase: Department of Thoracic Surgery, Institute of Oncology “Prof. Dr. Al. Trestioreanu” Bucharest, 022328 Bucharest, Romania
Daniela Luminița Zob: Department of Medical Oncology II, Institute of Oncology “Prof. Dr. Al. Trestioreanu” Bucharest, 022328 Bucharest, Romania
Adelina Silvana Gheorghe: Department of Oncology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
Cristian Virgil Lungulescu: Department of Oncology, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania
Elena Adriana Dumitrescu: Department of Oncology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
Dana Lucia Stănculeanu: Department of Oncology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
Loredana Sabina Cornelia Manolescu: Microbiology, Parasitology and Virology Discipline, Department of Fundamental Sciences, Faculty of Midwives and Nursing, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
Oana Popescu: Marius Nasta Institute of Pneumology, 050159 Bucharest, Romania
Elmira Ibraim: Marius Nasta Institute of Pneumology, 050159 Bucharest, Romania
Beatrice Mahler: Marius Nasta Institute of Pneumology, 050159 Bucharest, Romania

IJERPH, 2023, vol. 20, issue 2, 1-13

Abstract: Lung cancer and pulmonary tuberculosis are two significant public health problems that continue to take millions of lives each year. They may have similar symptoms and, in some cases, are diagnosed simultaneously or may have a causal relationship. In tuberculosis disease, the chronic inflammation, different produced molecules, genomic changes, and fibrosis are believed to be important factors that may promote carcinogenesis. As a reverse reaction, the development of carcinogenesis and the treatment may induce the reactivation of latent tuberculosis infection. Moreover, the recently used checkpoint inhibitors are a debatable subject since they help treat lung cancer but may lead to the reactivation of pulmonary tuberculosis and checkpoint-induced pneumonitis. Pulmonary rehabilitation is an effective intervention in post-tuberculosis patients and lung cancer patients and should be recommended to improve outcomes in these pathologies.

Keywords: lung cancer; tuberculosis; immune checkpoint inhibitors; carcinogenesis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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