Glutathione S-Transferase P1 Genetic Variant’s Influence on the HbA1c Level in Type Two Diabetic Patients

Katarzyna Orlewska (), Justyna Klusek, Stanisław Głuszek, Jolanta Klusek, Bartosz Witczak, Monika Wawszczak, Łukasz Madej, Michał Tomasz Marzec and Ewa Orlewska
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Katarzyna Orlewska: Collegium Medicum, Jan Kochanowski University, 25-516 Kielce, Poland
Justyna Klusek: Collegium Medicum, Jan Kochanowski University, 25-516 Kielce, Poland
Stanisław Głuszek: Collegium Medicum, Jan Kochanowski University, 25-516 Kielce, Poland
Jolanta Klusek: Institute of Biology, Jan Kochanowski University, 25-406 Kielce, Poland
Bartosz Witczak: Collegium Medicum, Jan Kochanowski University, 25-516 Kielce, Poland
Monika Wawszczak: Collegium Medicum, Jan Kochanowski University, 25-516 Kielce, Poland
Łukasz Madej: Collegium Medicum, Jan Kochanowski University, 25-516 Kielce, Poland
Michał Tomasz Marzec: Collegium Medicum, Jan Kochanowski University, 25-516 Kielce, Poland
Ewa Orlewska: Collegium Medicum, Jan Kochanowski University, 25-516 Kielce, Poland

IJERPH, 2023, vol. 20, issue 2, 1-9

Abstract: GST (glutathione S-transferases) are capable of influencing glucose homeostasis, probably through regulation of the response to oxidant stress. The aim of our study was to investigate the relationship between GSTP1 gene polymorphism and glycated hemoglobin (HbA1c) levels in type two diabetic (T2D) patients. A total of 307 T2D patients were included. Analysis of the GSTP1 gene polymorphism (rs1695) was conducted using the TaqMan qPCR method endpoint genotyping. HbA1c was determined using a COBAS 6000 autoanalyzer. A univariable linear regression and multivariable linear regression model were used to investigate the association between mean HbA1c level and GSTP1 gene polymorphism, age at T2D diagnosis, T2D duration, therapy with insulin, gender, BMI, smoking status. GSTP1 Val/Val genotype, age at T2D diagnosis, T2D duration and therapy with insulin were statistically significant contributors to HbA1c levels ( p < 0.05). Multivariable regression analysis revealed that GSTP1 (Val/Val vs. Ile/Ile) was associated with higher HbA1c even after adjustment for variables that showed a statistically significant relationship with HbA1c in univariable analyses ( p = 0.024). The results suggest that GSTP polymorphism may be one of the risk factors for higher HbA1c in T2D patients. Our study is limited by the relatively small sample size, cross-sectional design, and lack of inclusion of other oxidative stress-related genetic variants.

Keywords: diabetes; glutathione S-transferase; GSTP1; HbA1c (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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