Rotating Night Shift Work and Bladder Cancer Risk in Women: Results of Two Prospective Cohort Studies

Shahab Haghayegh, Yue Liu, Yin Zhang, Susanne Strohmaier, Kyriaki Papantoniou, Sarah Markt, Edward Giovannucci and Eva Schernhammer ()
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Shahab Haghayegh: Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA
Yue Liu: Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA
Yin Zhang: Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA 02115, USA
Susanne Strohmaier: Department of Epidemiology, Center for Public Health, Medical University of Vienna, 1090 Vienna, Austria
Kyriaki Papantoniou: Department of Epidemiology, Center for Public Health, Medical University of Vienna, 1090 Vienna, Austria
Sarah Markt: Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
Edward Giovannucci: Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA 02115, USA
Eva Schernhammer: Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA

IJERPH, 2023, vol. 20, issue 3, 1-9

Abstract: Bladder cancer is the sixth most common cancer in the United States. Night shift work has previously been linked with cancer risk. Whether there is an association between rotating night shift work and bladder cancer in women has not been studied previously. Eligible participants in the Nurses’ Health Study (NHS, n = 82,147, 1988–2016) and Nurses’ Health Study II (NHSII, n = 113,630, 1989–2015) were prospectively followed and a total of 620 and 122 incident bladder cancer cases were documented during the follow-up of NHS and NHSII, respectively. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) for bladder cancer incidence. We observed a significantly increased risk of bladder cancer among women with >5 years of night shift work history compared with women who never worked rotating night shifts in NHS (HR = 1.24; 95%CI = 1.01–1.54, p for trend = 0.06), but not in the pooled NHS and NHS II (HR = 1.18; 95%CI = 0.97–1.43, p for trend = 0.08). Secondary analyses stratified by smoking status showed no significant interaction ( p = 0.89) between the duration of rotating night shift work and smoking status. In conclusion, our results did not provide strong evidence for an association between rotating night shift work and bladder cancer risk.

Keywords: shiftwork; cancer; circadian rhythm (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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