Contribution of Solar Radiation and Pollution to Parkinson’s Disease

Isabella Karakis, Shaked Yarza, Yair Zlotnik, Gal Ifergane, Itai Kloog, Kineret Grant-Sasson and Lena Novack ()
Additional contact information
Isabella Karakis: Environmental Epidemiology Division, Israel Ministry of Health, Jerusalem 9446724, Israel
Shaked Yarza: Negev Environmental Health Research Institute, Soroka University Medical Center, Beer-Sheva P.O. Box 651, Israel
Yair Zlotnik: Neurology Department, Soroka University Medical Center, Beer-Sheva P.O. Box 651, Israel
Gal Ifergane: Neurology Department, Soroka University Medical Center, Beer-Sheva P.O. Box 651, Israel
Itai Kloog: Negev Environmental Health Research Institute, Soroka University Medical Center, Beer-Sheva P.O. Box 651, Israel
Kineret Grant-Sasson: Negev Environmental Health Research Institute, Soroka University Medical Center, Beer-Sheva P.O. Box 651, Israel
Lena Novack: Negev Environmental Health Research Institute, Soroka University Medical Center, Beer-Sheva P.O. Box 651, Israel

IJERPH, 2023, vol. 20, issue 3, 1-18

Abstract: Background . Parkinson’s disease (PD) is believed to develop from epigenetic modulation of gene expression through environmental factors that accounts for up to 85% of all PD cases. The main objective of this study was to examine the association between PD onset and a cumulative exposure to potentially modifiable ambient exposures. Methods . The study population comprised 3343 incident PD cases and 31,324 non-PD controls in Southern Israel. The exposures were determined based on the monitoring stations and averaged per year. Their association with PD was modeled using a distributed lag non-linear model and presented as an effect of exposure to the 75th percentile as compared to the 50th percentile of each pollutant, accumulated over the span of 5 years prior to the PD. Results . We recorded an adverse effect of particulate matter of size ≤10 μm in diameter (PM 10 ) and solar radiation (SR) with odds ratio (OR) = 1.06 (95%CI: 1.02; 1.10) and 1.23 (95%CI: 1.08; 1.39), respectively. Ozone (O 3 ) was also adversely linked to PD, although with a borderline significance, OR: 1.12 (95%CI: 0.99; 1.25). Immigrants arriving in Israel after 1989 appeared to be more vulnerable to exposure to O 3 and SR. The dose response effect of SR, non-existent for Israeli-born (OR = 0.67, 95%CI: 0.40; 1.13), moderate for immigrants before 1989 (OR = 1.17, 95%CI: 0.98; 1.40) and relatively high for new immigrants (OR = 1.25, 95%CI: 1.25; 2.38) indicates an adaptation ability to SR. Conclusions . Our findings supported previous reports on adverse association of PD with exposure to PM 10 and O 3 . Additionally, we revealed a link of Parkinson’s Disease with SR that warrants an extensive analysis by research groups worldwide.

Keywords: Parkinson’s disease; solar radiation; pollution; case-control study; immigrants; adaptation (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/20/3/2254/pdf (application/pdf)
https://www.mdpi.com/1660-4601/20/3/2254/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:20:y:2023:i:3:p:2254-:d:1047897

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().