Identifying the Biomarker Profile of Pre-Frail and Frail People: A Cross-Sectional Analysis from UK Biobank

Wenying Chu, Nathan Lynskey, James Iain-Ross, Jill P. Pell, Naveed Sattar, Frederick K. Ho, Paul Welsh, Carlos Celis-Morales and Fanny Petermann-Rocha ()
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Wenying Chu: BHF Cardiovascular Research Centre, School of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK
Nathan Lynskey: BHF Cardiovascular Research Centre, School of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK
James Iain-Ross: BHF Cardiovascular Research Centre, School of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK
Jill P. Pell: School of Health and Wellbeing, University of Glasgow, Glasgow G12 8RZ, UK
Naveed Sattar: BHF Cardiovascular Research Centre, School of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK
Frederick K. Ho: School of Health and Wellbeing, University of Glasgow, Glasgow G12 8RZ, UK
Paul Welsh: School of Health and Wellbeing, University of Glasgow, Glasgow G12 8RZ, UK
Carlos Celis-Morales: School of Health and Wellbeing, University of Glasgow, Glasgow G12 8RZ, UK
Fanny Petermann-Rocha: BHF Cardiovascular Research Centre, School of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK

IJERPH, 2023, vol. 20, issue 3, 1-13

Abstract: Objective: This study aimed to compare the biomarker profile of pre-frail and frail adults in the UK Biobank cohort by sex. Methods: In total, 202,537 participants (67.8% women, aged 37 to 73 years) were included in this cross-sectional analysis. Further, 31 biomarkers were investigated in this study. Frailty was defined using a modified version of the Frailty Phenotype. Multiple linear regression analyses were performed to explore the biomarker profile of pre-frail and frail individuals categorized by sex. Results: Lower concentrations of apoA1, total, LDL, and HDL cholesterol, albumin, eGFRcys, vitamin D, total bilirubin, apoB, and testosterone (differences ranged from −0.30 to −0.02 per 1-SD change), as well as higher concentrations of triglycerides, GGT, cystatin C, CRP, ALP, and phosphate (differences ranged from 0.01 to 0.53 per 1-SD change), were identified both in pre-frail and frail men and women. However, some of the associations differed by sex. For instance, higher rheumatoid factor and urate concentrations were identified in pre-frail and frail women, while lower calcium, total protein, and IGF-1 concentrations were identified in pre-frail women and frail women and men. When the analyses were further adjusted for CRP, similar results were found. Conclusions: Several biomarkers were linked to pre-frailty and frailty. Nonetheless, some of the associations differed by sex. Our findings contribute to a broader understanding of the pathophysiology of frailty as currently defined.

Keywords: frailty; aging; biomarkers; UK Biobank (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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