Latent Trajectories of Haematological, Hepatic, and Renal Profiles after Oil Spill Exposure: A Longitudinal Analysis

Benjamin Atta Owusu, Apiradee Lim, Nitinun Pongsiri, Chanthip Intawong, Sunthorn Rheanpumikankit, Saijit Suksri and Thammasin Ingviya ()
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Benjamin Atta Owusu: Department of Mathematics and Computer Science, Faculty of Science and Technology, Prince of Songkla University, Pattani Campus, Pattani 94000, Thailand
Apiradee Lim: Department of Mathematics and Computer Science, Faculty of Science and Technology, Prince of Songkla University, Pattani Campus, Pattani 94000, Thailand
Nitinun Pongsiri: Department of Mathematics and Computer Science, Faculty of Science and Technology, Prince of Songkla University, Pattani Campus, Pattani 94000, Thailand
Chanthip Intawong: Occupational Medicine Department, Rayong Hospital, Rayong 21000, Thailand
Sunthorn Rheanpumikankit: Rayong Provincial Public Health Office, Rayong 21000, Thailand
Saijit Suksri: Rayong Provincial Public Health Office, Rayong 21000, Thailand
Thammasin Ingviya: Air Pollution and Health Effect Research Center, Prince of Songkla University, Hat Yai Campus, Songkhla 90110, Thailand

IJERPH, 2023, vol. 20, issue 4, 1-14

Abstract: Exposure to polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs) in crude oil has carcinogenic effects on various organ systems. This longitudinal cohort study examined the effects of oil spill exposure on the haematological, hepatic, and renal profiles of Rayong oil spill clean-up workers. The sample included 869 clean-up workers from the Rayong oil spill. Latent class mixture models were used to investigate and classify the longitudinal trajectories and trends of the haematological, hepatic, and renal indices. Subgroup analysis was used to evaluate the association between the urinary metabolites of PAHs and VOCs and haematological, hepatic, and renal parameters. Most clean-up workers (97.6%) had increasing levels of white blood cells (WBCs) (0.03 × 10 3 cells/µL), 94.90% of the workers had a significantly increasing trend of blood urea nitrogen (0.31 mg/dL per year), and 87.20% had a significantly increasing trend of serum creatinine (0.01 mg/dL per year). A high–decreasing trend of WBCs was seen in 2.42% (−0.73 × 10 3 per year). Post-exposure changes in haematological, renal, and hepatic profiles are present in workers exposed to the Rayong oil spill. This indicates possible long-term health complications and worsening renal function after exposure to PAHs and VOCs in crude oil.

Keywords: longitudinal trajectories; haematological profile; kidney function; liver function; latent classes (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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