The Effects of Resistance Exercise on the Cardiorespiratory Tissue of Rats with Parkinson’s Disease

Graziele Mayra Santos Moreira, Laila Cristina Moreira Damázio (), Silvana Venâncio da Silva, Augusto Targino Silveira, Isabella Giordano Mesquita, Luana Aparecida de Sousa Silva, Luan Alves Pereira, Ana Clara Silva Costa, Ismael Augusto Lima Santos, Maria Eduarda Paiva Campos, Luna Sara Campos Vaz, Zenaide Alves Cardoso, José Victor Ribeiro Silva Gomes, Paulo Henrique Almeida Campos Júnior and Liliam Midori Ide
Additional contact information
Graziele Mayra Santos Moreira: Graduate Program in Morphofunctional Sciences (PPGCM), Federal University of São João del-Rei (UFSJ), Sao Joao del Rei 36307-352, Brazil
Laila Cristina Moreira Damázio: Graduate Program in Morphofunctional Sciences (PPGCM), Federal University of São João del-Rei (UFSJ), Sao Joao del Rei 36307-352, Brazil
Silvana Venâncio da Silva: Graduate Program in Morphofunctional Sciences (PPGCM), Federal University of São João del-Rei (UFSJ), Sao Joao del Rei 36307-352, Brazil
Augusto Targino Silveira: Physiotherapy Department, Presidente Tancredo de Almeida Neves University Center (UNIPTAN/Afya), São João del Rei 36307-251, Brazil
Isabella Giordano Mesquita: Medicine and Biological Sciences Course, Dom Bosco Campus, Federal University of São João del-Rei (UFSJ), Sao Joao del Rei 36301-158, Brazil
Luana Aparecida de Sousa Silva: Medicine and Biological Sciences Course, Dom Bosco Campus, Federal University of São João del-Rei (UFSJ), Sao Joao del Rei 36301-158, Brazil
Luan Alves Pereira: Medicine and Biological Sciences Course, Dom Bosco Campus, Federal University of São João del-Rei (UFSJ), Sao Joao del Rei 36301-158, Brazil
Ana Clara Silva Costa: Medicine and Biological Sciences Course, Dom Bosco Campus, Federal University of São João del-Rei (UFSJ), Sao Joao del Rei 36301-158, Brazil
Ismael Augusto Lima Santos: Medicine and Biological Sciences Course, Dom Bosco Campus, Federal University of São João del-Rei (UFSJ), Sao Joao del Rei 36301-158, Brazil
Maria Eduarda Paiva Campos: Medicine and Biological Sciences Course, Dom Bosco Campus, Federal University of São João del-Rei (UFSJ), Sao Joao del Rei 36301-158, Brazil
Luna Sara Campos Vaz: Medicine and Biological Sciences Course, Dom Bosco Campus, Federal University of São João del-Rei (UFSJ), Sao Joao del Rei 36301-158, Brazil
Zenaide Alves Cardoso: Medicine and Biological Sciences Course, Dom Bosco Campus, Federal University of São João del-Rei (UFSJ), Sao Joao del Rei 36301-158, Brazil
José Victor Ribeiro Silva Gomes: Medicine and Biological Sciences Course, Dom Bosco Campus, Federal University of São João del-Rei (UFSJ), Sao Joao del Rei 36301-158, Brazil
Paulo Henrique Almeida Campos Júnior: Graduate Program in Morphofunctional Sciences (PPGCM), Federal University of São João del-Rei (UFSJ), Sao Joao del Rei 36307-352, Brazil
Liliam Midori Ide: Graduate Program in Morphofunctional Sciences (PPGCM), Federal University of São João del-Rei (UFSJ), Sao Joao del Rei 36307-352, Brazil

IJERPH, 2023, vol. 20, issue 4, 1-10

Abstract: Parkinson’s Disease (PD) affects the cardiorespiratory system, causing an increase in the left ventricular mass in the heart and respiratory muscle weakness in relation to healthy individuals. The objective of this study was to investigate the effects of progressive resistive physical exercise on the vertical ladder on the histomorphometry of cardiac tissue and respiratory muscles in rats with PD. Seventy male Wistar rats, aged 40 days old, were divided into Parkinson’s (PD) and Sham (SH) groups; they were also subdivided into groups that performed progressive resistive physical exercise on the vertical ladder Before Surgery (ExBS), After Surgery (ExAS), and Before and After Surgery (ExBAS). The physical training was carried out before and/or after PD induction. Exercise was performed five times a week for 25 min/day for four or eight weeks. PD induction was conducted via electrolytic stimulation of the Substantia nigra of the animals’ brains, adopting the following stereotaxic table coordinates: −4.9; lateral medium equal to 1.7, and dorsoventral equal to 8.1. For the morphometric analysis of the heart, the following variables were calculated: relative weight and diameter and thickness of the left ventricle. The diaphragm and the myocardial, intercostal, and abdominal muscles were stained with Hematoxylin and Eosin (HE). The histomorphometric analysis was performed using the ImageJ software to assess the cross-sectional area of muscles and the number of muscle fibers. Progressive resistance exercise promoted the hypertrophy of respiratory muscles and the left ventricle in animals with PD.

Keywords: Parkinson’s disease; exercise; heart; muscles (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/20/4/2925/pdf (application/pdf)
https://www.mdpi.com/1660-4601/20/4/2925/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:20:y:2023:i:4:p:2925-:d:1061129

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().