Long-Acting Injectable Antipsychotic Treatment during Pregnancy: A Case Series

Georgios Eleftheriou (), Raffaella Butera, Anna Sangiovanni, Claudia Palumbo and Emi Bondi
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Georgios Eleftheriou: Poison Control Center and Teratology Information Center, ASST Papa Giovanni XXIII, 24100 Bergamo, Italy
Raffaella Butera: Poison Control Center, ASST Papa Giovanni XXIII, 24100 Bergamo, Italy
Anna Sangiovanni: Poison Control Center, ASST Papa Giovanni XXIII, 24100 Bergamo, Italy
Claudia Palumbo: Department of Psychiatry, ASST Papa Giovanni XXIII, 24100 Bergamo, Italy
Emi Bondi: Department of Psychiatry, ASST Papa Giovanni XXIII, 24100 Bergamo, Italy

IJERPH, 2023, vol. 20, issue 4, 1-7

Abstract: Introduction: Data from the literature show that prolonged-release injectable antipsychotics (LAIs) ensure constant blood drug levels better patient compliance and offer a simpler treatment regimen for both patients and caregivers. This observational–descriptive study aims to detect the possible complications found in newborns of women with bipolar or psychotic disorders and LAI therapy during pregnancy. Methods: This study involved women with psychotic disorders during pregnancy who contacted the Teratology Information Center of Bergamo, Italy between 2016 and 2021 to receive counseling on the possible risks of exposure to LAI therapy. The follow-up procedure was carried out by telephone interview or direct contact with the patient and/or her physician. Results: In this study, LAI treatment in pregnancy was not associated with an increased risk of malformations. All but one of the children in the sample were born healthy and the mothers maintained psychopathological compensation during pregnancy. Conclusions: This study showed that, despite the small size of the sample under examination, the administration of LAIs do not compromise the normal intrauterine development of the unborn child and there were no evident major malformations.

Keywords: long-acting injectable antipsychotics; pregnancy; neonatal outcome (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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