Associations between Anxiety, Depression, Chronic Pain and Oral Health-Related Quality of Life, Happiness, and Polymorphisms in Adolescents’ Genes

Ana Luiza Peres Baldiotti, Gabrielle Amaral-Freitas, Mariane Carolina Faria Barbosa, Paula Rocha Moreira, Renato Assis Machado, Ricardo Della Coletta, Michelle Nascimento Meger, Saul Martins Paiva, Rafaela Scariot and Fernanda de Morais Ferreira ()
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Ana Luiza Peres Baldiotti: Department of Pediatric Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Gabrielle Amaral-Freitas: Department of Pediatric Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Mariane Carolina Faria Barbosa: Department of Pediatric Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Paula Rocha Moreira: Department of Morphology, Institute of Biological Sciences (ICB), Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Renato Assis Machado: Department of Oral Diagnosis and Graduate Program in Oral Biology, School of Dentistry, University of Campinas, Piracicaba 13414-903, SP, Brazil
Ricardo Della Coletta: Department of Oral Diagnosis and Graduate Program in Oral Biology, School of Dentistry, University of Campinas, Piracicaba 13414-903, SP, Brazil
Michelle Nascimento Meger: School of Health and Biological Sciences, Universidade Positivo, Curitiba 81290-000, PR, Brazil
Saul Martins Paiva: Department of Pediatric Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil
Rafaela Scariot: Departament of Oral Surgery and Maxilofacial, Federal University of Paraná, Curitiba 81530-000, PR, Brazil
Fernanda de Morais Ferreira: Department of Pediatric Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil

IJERPH, 2023, vol. 20, issue 4, 1-11

Abstract: Adolescence is marked by changes and vulnerability to the emergence of psychological problems. This study aimed to investigate associations between anxiety/depression/chronic pain and oral health-related quality of life (OHRQoL)/happiness/polymorphisms in the COMT , HTR2A and FKBP5 genes in Brazilian adolescents. A cross-sectional study was conducted with ninety adolescents 13 to 18 years. Anxiety, depression and chronic pain were evaluated using the RDC/TMD. The Oral Health Impact Profile was used to assess oral OHRQoL. The Subjective Happiness Scale was used to assess happiness. Single-nucleotide polymorphisms in COMT (rs165656, rs174675), HTR2A (rs6313, rs4941573) and FKBP5 (rs1360780, rs3800373) were genotyped using the Taqman ® method. Bivariate and multivariate logistic regression analyses were performed ( p < 0.05). Chronic pain and depression were associated with feelings of happiness ( p < 0.05). A significant inverse association was found between anxiety and OHRQoL ( p = 0.004). The presence of minor allele C of COMT rs174675 was significantly associated with depression ( p = 0.040). Brazilian adolescents with depression and chronic pain considers themselves to be less happy than others and those with anxiety are more likely to have a negative impact on OHRQoL. Moreover, the rs174675 variant allele in the COMT gene was associated with depressive symptoms in Brazilian adolescents.

Keywords: adolescent; happiness; anxiety; depression; chronic pain; quality of life; genetic polymorphisms (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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