Targeted Lipidomics and Inflammation Response to Six Weeks of Sprint Interval Training in Male Adolescents

Aozhe Wang, Haifeng Zhang, Jianming Liu, Zhiyi Yan, Yaqi Sun, Wantang Su, Ji-Guo Yu, Jing Mi () and Li Zhao ()
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Aozhe Wang: Department of Exercise Physiology, Beijing Sport University, Beijing 100084, China
Haifeng Zhang: Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China
Jianming Liu: School of Competitive Sports, Beijing Sport University, Beijing 100084, China
Zhiyi Yan: Department of Exercise Physiology, Beijing Sport University, Beijing 100084, China
Yaqi Sun: Department of Exercise Physiology, Beijing Sport University, Beijing 100084, China
Wantang Su: Department of Exercise Physiology, Beijing Sport University, Beijing 100084, China
Ji-Guo Yu: Department of Community Medicine and Rehabilitation, Faculty of Medicine, Umeå University, 901 87 Umeå, Sweden
Jing Mi: School of Competitive Sports, Beijing Sport University, Beijing 100084, China
Li Zhao: Department of Exercise Physiology, Beijing Sport University, Beijing 100084, China

IJERPH, 2023, vol. 20, issue 4, 1-15

Abstract: Lipids play an important role in coordinating and regulating metabolic and inflammatory processes. Sprint interval training (SIT) is widely used to improve sports performance and health outcomes, but the current understanding of SIT-induced lipid metabolism and the corresponding systemic inflammatory status modification remains controversial and limited, especially in male adolescents. To answer these questions, twelve untrained male adolescents were recruited and underwent 6 weeks of SIT. The pre- and post-training testing included analyses of peak oxygen consumption (VO 2 peak), biometric data (weight and body composition), serum biochemical parameters (fasting blood glucose, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triacylglycerol, testosterone, and cortisol), inflammatory markers, and targeted lipidomics. After the 6-week SIT, the serum C-reactive protein (CRP), interleukin (IL)-1β, IL-2, IL-4, IL-10, tumor necrosis factor (TNF)-α, and transforming growth factor (TGF)-β significantly decreased ( p < 0.05), whereas IL-6 and IL-10/TNF-α significantly increased ( p < 0.05). In addition, the targeted lipidomics revealed changes in 296 lipids, of which 33 changed significantly ( p < 0.05, fold change > 1.2 or <1/1.2). The correlation analysis revealed that the changes in the inflammatory markers were closely correlated with the changes in some of the lipids, such as LPC, HexCer, and FFA. In conclusion, the 6-week SIT induced significant changes in the inflammatory markers and circulating lipid composition, offering health benefits to the population.

Keywords: sprint interval training; inflammation; lipidomics; male adolescent (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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