Association between Serum Uric Acid Levels and Bone Mineral Density in Taiwanese Elderly Population

Pei-Ting Chung, Hsiao-Chi Ma, Sin-Yi Huang, Hsin-Ning Lien, Kuan-Hsun Ho, Hsin-Yin Hsu, Lee-Ching Hwang, Meng-Ting Tsou, Hsin-Hui Lin () and Hsin-Lung Chan ()
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Pei-Ting Chung: Department of Family Medicine, Mackay Memorial Hospital, Taipei 104217, Taiwan
Hsiao-Chi Ma: Department of Family Medicine, Mackay Memorial Hospital, Tamsui Branch, New Taipei City 251020, Taiwan
Sin-Yi Huang: Department of Family Medicine, Mackay Memorial Hospital, Taipei 104217, Taiwan
Hsin-Ning Lien: Department of Family Medicine, Mackay Memorial Hospital, Taipei 104217, Taiwan
Kuan-Hsun Ho: Department of Family Medicine, Mackay Memorial Hospital, Taipei 104217, Taiwan
Hsin-Yin Hsu: Department of Family Medicine, Mackay Memorial Hospital, Taipei 104217, Taiwan
Lee-Ching Hwang: Department of Family Medicine, Mackay Memorial Hospital, Taipei 104217, Taiwan
Meng-Ting Tsou: Department of Family Medicine, Mackay Memorial Hospital, Taipei 104217, Taiwan
Hsin-Hui Lin: Department of Family Medicine, Mackay Memorial Hospital, Tamsui Branch, New Taipei City 251020, Taiwan
Hsin-Lung Chan: Department of Family Medicine, Mackay Memorial Hospital, Taipei 104217, Taiwan

IJERPH, 2023, vol. 20, issue 4, 1-8

Abstract: Osteoporosis is a progressive metabolic bone disorder characterised by a decline in bone mineral density (BMD). Some previous studies have reported a controversial relationship between uric acid and osteoporosis. This cross-sectional study aimed to assess the association between serum uric acid levels and BMD in older adults from Taiwan. Data from participants aged ≥ 60 years were collected from 2008 to 2018. Furthermore, the participants were classified based on uric acid level quartiles. Regression models were used to assess the association between uric acid levels and bone health, including BMD values and risk of at least osteopenia. Crude and adjusted models of potential confounders, including age, sex and body mass index (BMI), were used. Compared with the first quartile of uric acid levels, the odds ratios for osteoporosis decreased in the higher uric acid level groups after adjustment for age, sex and BMI. The boxplot analysis showed that BMD values were higher in the groups with higher uric acid levels; moreover, the results of the multivariable linear regression model showed a consistent pattern. Notably, uric acid levels were positively correlated with BMD values. Higher uric acid levels in the elderly population might decrease the risk of at least osteopenia. As opposed to the anti-hyperuricemic policy for younger adults with a relatively lower risk of osteoporosis, BMD evaluation and urate-lowering therapy, goal adjustments should be considered for older adults with lower uric acid levels.

Keywords: osteoporosis; osteopenia; bone mineral density; hyperuricemia (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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