The Role of Preoperative Chronic Statin Therapy in Heart Transplant Receipts—A Retrospective Single-Center Cohort Study

Dragos-Florin Baba (), Horatiu Suciu, Calin Avram (), Alina Danilesco, Diana Andreea Moldovan, Radu Catalin Rauta, Laurentiu Huma and Ileana Anca Sin
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Dragos-Florin Baba: Emergency Institute for Cardiovascular Diseases and Transplantation, 540142 Targu Mures, Romania
Horatiu Suciu: Emergency Institute for Cardiovascular Diseases and Transplantation, 540142 Targu Mures, Romania
Calin Avram: Department of Medical Informatics and Biostatistics, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540142 Targu Mures, Romania
Alina Danilesco: Department of Cell and Molecular Biology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540142 Targu Mures, Romania
Diana Andreea Moldovan: Emergency Institute for Cardiovascular Diseases and Transplantation, 540142 Targu Mures, Romania
Radu Catalin Rauta: Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540142 Targu Mures, Romania
Laurentiu Huma: Emergency Institute for Cardiovascular Diseases and Transplantation, 540142 Targu Mures, Romania
Ileana Anca Sin: Department of Cell and Molecular Biology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, 540142 Targu Mures, Romania

IJERPH, 2023, vol. 20, issue 4, 1-13

Abstract: Background: Statin therapy has been proven to reduce the risk of cardiovascular events. The objective of our retrospective study was to investigate the relationship between preoperative chronic administration of statins to postoperative 2-month heart transplantation complications. Methods: A total number of 38 heart transplantation recipients from the Cardiovascular and Transplant Emergency Institute of Târgu Mureș between May 2014 and January 2021 were included in our study. Results: In logistic regression, we found a statistical significance between statin treatment and the presence of postoperative complications of any cause (OR: 0.06, 95% CI: 0.008–0.56; p = 0.0128), simultaneously presenting an elevated risk for early-postoperative acute kidney injury (AKI). From the statin group, atorvastatin therapy had a higher risk of type 2 diabetes mellitus (T2DM) development (OR: 29.73, 95% CI: 1.19–741.76; p = 0.0387) and AKI (OR: 29.73, 95% CI: 1.19–741.76; p = 0.0387). C-reactive protein (CRP), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-c) represented risk factors, atorvastatin administration being independently associated with lower CRP values. Conclusions: Chronic previous administration of statins represented a protective factor to the development of 2-month postoperative complications of any cause in heart transplant receipts.

Keywords: statin; atorvastatin; C-reactive protein; heart transplant; complications (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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