Sex Differences in Multimorbidity, Inappropriate Medication and Adverse Outcomes of Inpatient Care: MoPIM Cohort Study

Marisa Baré (), Marina Lleal, Daniel Sevilla-Sánchez, Sara Ortonobes, Susana Herranz, Olivia Ferrandez, Celia Corral-Vázquez, Núria Molist, Gloria Julia Nazco, Candelaria Martín-González, Miguel Ángel Márquez and on behalf of the MoPIM Study Group
Additional contact information
Marisa Baré: Institutional Committee for the Improvement of Clinical Practice Adequacy, Clinical Epidemiology and Cancer Screening Department, CRiSP Research Group, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT), 08208 Sabadell, Spain
Marina Lleal: Institutional Committee for the Improvement of Clinical Practice Adequacy, Clinical Epidemiology and Cancer Screening Department, CRiSP Research Group, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT), 08208 Sabadell, Spain
Daniel Sevilla-Sánchez: Pharmacy Department, Parc Sanitari Pere Virgili, 08023 Barcelona, Spain
Sara Ortonobes: Pharmacy Department, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT), Universitat Autònoma de Barcelona, 08208 Sabadell, Spain
Susana Herranz: Research Network on Health Services in Chronic Patients (REDISSEC), Instituto de Salud Carlos III, 28029 Madrid, Spain
Olivia Ferrandez: Pharmacy Department, Consorci Parc de Salut MAR, 08003 Barcelona, Spain
Celia Corral-Vázquez: Research Network on Health Services in Chronic Patients (REDISSEC), Instituto de Salud Carlos III, 28029 Madrid, Spain
Núria Molist: Geriatrics Department-C3RG Research Ggoup, Consorci Hospitalari de Vic, 08500 Vic, Spain
Gloria Julia Nazco: Pharmacy Department, Hospital Universitario de Canarias, 38320 La Laguna, Spain
Candelaria Martín-González: Internal Medicine Department, Hospital Universitario de Canarias, 38320 La Laguna, Spain
Miguel Ángel Márquez: Geriatrics Department, Consorci Parc de Salut MAR, 08003 Barcelona, Spain
on behalf of the MoPIM Study Group: Membership of the Group Name is provided in the Acknowledgments.

IJERPH, 2023, vol. 20, issue 4, 1-15

Abstract: There is no published evidence on the possible differences in multimorbidity, inappropriate prescribing, and adverse outcomes of care, simultaneously, from a sex perspective in older patients. We aimed to identify those possible differences in patients hospitalized because of a chronic disease exacerbation. A multicenter, prospective cohort study of 740 older hospitalized patients (≥65 years) was designed, registering sociodemographic variables, frailty, Barthel index, chronic conditions (CCs), geriatric syndromes (GSs), polypharmacy, potentially inappropriate prescribing (PIP) according to STOPP/START criteria, and adverse drug reactions (ADRs). Outcomes were length of stay (LOS), discharge to nursing home, in-hospital mortality, cause of mortality, and existence of any ADR and its worst consequence. Bivariate analyses between sex and all variables were performed, and a network graph was created for each sex using CC and GS. A total of 740 patients were included (53.2% females, 53.5% ≥85 years old). Women presented higher prevalence of frailty, and more were living in a nursing home or alone, and had a higher percentage of PIP related to anxiolytics or pain management drugs. Moreover, they presented significant pairwise associations between CC, such as asthma, vertigo, thyroid diseases, osteoarticular diseases, and sleep disorders, and with GS, such as chronic pain, constipation, and anxiety/depression. No significant differences in immediate adverse outcomes of care were observed between men and women in the exacerbation episode.

Keywords: sex perspective; multimorbidity; network analysis; potentially inappropriate medication; adverse drug reaction; in-hospital mortality; outcomes of care (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:20:y:2023:i:4:p:3639-:d:1072809

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