The Role of Magnetic Transcranial Stimulation in the Diagnosis and Post-Surgical Follow-Up of Cervical Spondylotic Myelopathy

Fernando Vázquez-Sánchez, María del Carmen Lloria-Gil, Ana Isabel Gómez-Menéndez, Francisco Isidro-Mesas, Ana Echavarría-Íñiguez, Javier Martín-Alonso, Jerónimo González-Bernal (), Josefa González-Santos (), Anna Berardi, Marco Tofani, Giovanni Galeoto and Beatriz García-López
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Fernando Vázquez-Sánchez: Neurophysiology Department, Burgos University Hospital, 09006 Burgos, Spain
María del Carmen Lloria-Gil: Neurophysiology Department, Burgos University Hospital, 09006 Burgos, Spain
Ana Isabel Gómez-Menéndez: Neurophysiology Department, Burgos University Hospital, 09006 Burgos, Spain
Francisco Isidro-Mesas: Neurophysiology Department, Burgos University Hospital, 09006 Burgos, Spain
Ana Echavarría-Íñiguez: Neurology Department, Valladolid Clinical University Hospital, 47003 Valladolid, Spain
Javier Martín-Alonso: Neurosurgery Department, Burgos University Hospital, 09006 Burgos, Spain
Jerónimo González-Bernal: Department of Health Sciences, Burgos University, 09001 Burgos, Spain
Josefa González-Santos: Department of Health Sciences, Burgos University, 09001 Burgos, Spain
Anna Berardi: Department of Human Neurosciences, Sapienza University of Rome, 00185 Rome, Italy
Marco Tofani: Department of Human Neurosciences, Sapienza University of Rome, 00185 Rome, Italy
Giovanni Galeoto: Department of Human Neurosciences, Sapienza University of Rome, 00185 Rome, Italy
Beatriz García-López: Neurophysiology Department, Burgos University Hospital, 09006 Burgos, Spain

IJERPH, 2023, vol. 20, issue 4, 1-12

Abstract: Degenerative cervical myelopathy (DCM) consists of spinal cord damage due to its compression through the cervical spine. The leading cause is degenerative. The diagnosis is clinical, and the therapeutic approach is usually surgical. Confirmation of the diagnostic suspicion is done by magnetic resonance imaging (MRI); however, this test lacks functional information of the spinal cord, the abnormality of which may precede involvement in neuroimaging. Neurophysiological examination using somatosensory evoked potentials (SSEPs) and transcranial magnetic stimulation (TMS) allows for an evaluation of spinal cord function, and provides information in the diagnostic process. Its role in the post-surgical follow-up of patients undergoing decompressive surgery is being studied. We present a retrospective study of 24 patients with DCM and surgical decompression who underwent neurophysiological tests (TMS and SSEP) before, 6, and 12 months after surgery. The result of the TMS and the SSEP in the post-operative follow-up did not correlate with the clinical outcome, either subjective or measured by clinical scales at six months. We only found post-surgical improvement of central conduction times (CMCTs) in patients with severe pre-surgical motor impairment on TMS. In patients with normal pre-surgical CMCT, we found a transient worsening with return to baseline at the one-year follow-up. Most patients presented pre-surgical increased P40 latency at diagnosis. CMCT and SSEP were more related to clinical outcomes one year after the surgical procedure and were very useful in diagnosing.

Keywords: myelopathy; spinal cord; cervical spondylotic myelopathy (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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