Association between Glutathione S-Transferases Gene Variants and COVID-19 Severity in Previously Vaccinated and Unvaccinated Polish Patients with Confirmed SARS-CoV-2 Infection

Katarzyna Orlewska (), Justyna Klusek, Dorota Zarębska-Michaluk, Kamila Kocańda, Ruslan Oblap, Anna Cedro, Bartosz Witczak, Jolanta Klusek, Andrzej Śliwczyński and Ewa Orlewska
Additional contact information
Katarzyna Orlewska: Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland
Justyna Klusek: Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland
Dorota Zarębska-Michaluk: Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland
Kamila Kocańda: Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland
Ruslan Oblap: Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland
Anna Cedro: Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland
Bartosz Witczak: Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland
Jolanta Klusek: Institute of Biology, Jan Kochanowski University, 25-406 Kielce, Poland
Andrzej Śliwczyński: Faculty of Medicine, Lazarski University, 02-662 Warsaw, Poland
Ewa Orlewska: Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, Poland

IJERPH, 2023, vol. 20, issue 4, 1-11

Abstract: As the outcome of COVID-19 is associated with oxidative stress, it is highly probable that polymorphisms of genes related to oxidative stress were associated with susceptibility and severity of COVID-19. The aim of the study was to assess the association of glutathione S-transferases (GSTs) gene polymorphisms with COVID-19 severity in previously vaccinated and unvaccinated Polish patients with confirmed SARS-CoV-2 infection. A total of 92 not vaccinated and 84 vaccinated patients hospitalized due to COVID-19 were included. The WHO COVID-19 Clinical Progression Scale was used to assess COVID-19 severity. GSTs genetic polymorphisms were assessed by appropriate PCR methods. Univariable and multivariable analyses were performed, including logistic regression analysis. GSTP1 Ile/Val genotype was found to be associated with a higher risk of developing a severe form of the disease in the population of vaccinated patients with COVID-19 (OR: 2.75; p = 0.0398). No significant association was observed for any of the assessed GST genotypes with COVID-19 disease severity in unvaccinated patients with COVID-19. In this group of patients, BMI > 25 and serum glucose level > 99 mg% statistically significantly increased the odds towards more severe COVID-19. Our results may contribute to further understanding of risk factors of severe COVID-19 and selecting patients in need of strategies focusing on oxidative stress.

Keywords: COVID-19; SARS-CoV-2; glutathione S-transferase; oxidative stress; GSTP1 (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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