A Single Bout of Remote Ischemic Preconditioning Suppresses Ischemia-Reperfusion Injury in Asian Obese Young Men

Min-Hyeok Jang, Dae-Hwan Kim, Jean-Hee Han, Jahyun Kim and Jung-Hyun Kim ()
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Min-Hyeok Jang: Department of Physical Education, General Graduate School, Kyung Hee University, Yongin-si 17104, Republic of Korea
Dae-Hwan Kim: Department of Physical Education, General Graduate School, Kyung Hee University, Yongin-si 17104, Republic of Korea
Jean-Hee Han: Department of Physical Education, General Graduate School, Kyung Hee University, Yongin-si 17104, Republic of Korea
Jahyun Kim: Department of Kinesiology, California State University Bakersfield, Bakersfield, CA 93311, USA
Jung-Hyun Kim: Department of Sports Medicine, Kyung Hee University, Yongin-si 17104, Republic of Korea

IJERPH, 2023, vol. 20, issue 5, 1-9

Abstract: Remote ischemic preconditioning (RIPC) has been shown to minimize subsequent ischemia-reperfusion injury (IRI), whereas obesity has been suggested to attenuate the efficacy of RIPC in animal models. The primary objective of this study was to investigate the effect of a single bout of RIPC on the vascular and autonomic response after IRI in young obese men. A total of 16 healthy young men (8 obese and 8 normal weight) underwent two experimental trials: RIPC (three cycles of 5 min ischemia at 180 mmHg + 5 min reperfusion on the left thigh) and SHAM (the same RIPC cycles at resting diastolic pressure) following IRI (20 min ischemia at 180 mmHg + 20 min reperfusion on the right thigh). Heart rate variability (HRV), blood pressure (SBP/DBP), and cutaneous blood flow (CBF) were measured between baseline, post-RIPC/SHAM, and post-IRI. The results showed that RIPC significantly improved the LF/HF ratio ( p = 0.027), SBP ( p = 0.047), MAP ( p = 0.049), CBF ( p = 0.001), cutaneous vascular conductance ( p = 0.003), vascular resistance ( p = 0.001), and sympathetic reactivity (SBP: p = 0.039; MAP: p = 0.084) after IRI. However, obesity neither exaggerated the degree of IRI nor attenuated the conditioning effects on the measured outcomes. In conclusion, a single bout of RIPC is an effective means of suppressing subsequent IRI and obesity, at least in Asian young adult men, does not significantly attenuate the efficacy of RIPC.

Keywords: remote ischemic preconditioning; cutaneous blood flow; sympathetic reactivity; heart rate variability; obesity (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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