Oesophageal Atresia: Prevalence in the Valencian Region (Spain) and Associated Anomalies

Adriana Agurto-Ramírez, Laura García-Villodre (), Ana Ruiz-Palacio, Berta Arribas-Díaz, Laia Barrachina-Bonet, Lucía Páramo-Rodríguez, Óscar Zurriaga and Clara Cavero-Carbonell
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Adriana Agurto-Ramírez: Service of Preventive Medicine, Valencia General University Hospital Consortium, 46014 Valencia, Spain
Laura García-Villodre: Rare Diseases Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region-Valencia University (FISABIO-UVEG), 46020 Valencia, Spain
Ana Ruiz-Palacio: Rare Diseases Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region-Valencia University (FISABIO-UVEG), 46020 Valencia, Spain
Berta Arribas-Díaz: Rare Diseases Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region-Valencia University (FISABIO-UVEG), 46020 Valencia, Spain
Laia Barrachina-Bonet: Rare Diseases Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region-Valencia University (FISABIO-UVEG), 46020 Valencia, Spain
Lucía Páramo-Rodríguez: Rare Diseases Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region-Valencia University (FISABIO-UVEG), 46020 Valencia, Spain
Óscar Zurriaga: Rare Diseases Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region-Valencia University (FISABIO-UVEG), 46020 Valencia, Spain
Clara Cavero-Carbonell: Rare Diseases Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region-Valencia University (FISABIO-UVEG), 46020 Valencia, Spain

IJERPH, 2023, vol. 20, issue 5, 1-12

Abstract: The objective was to determine the prevalence of oesophageal atresia (OA) and describe the characteristics of OA cases diagnosed before the first year of life, born between 2007 and 2019, and residents in the Valencian Region (VR), Spain. Live births (LB), stillbirths (SB), and termination of pregnancy for fetal anomaly (TOPFA) diagnosed with OA were selected from the Congenital Anomalies population-based Registry of VR (RPAC-CV). The prevalence of OA per 10,000 births with 95% confidence interval was calculated, and socio-demographic and clinical variables were analyzed. A total of 146 OA cases were identified. The overall prevalence was 2.4/10,000 births, and prevalence by type of pregnancy ending was 2.3 in LB and 0.03 in both SB and TOPFA. A mortality rate of 0.03/1000 LB was observed. A relationship was found between case mortality and birth weight ( p -value < 0.05). OA was primarily diagnosed at birth (58.2%) and 71.2% of the cases were associated with another congenital anomaly, mainly congenital heart defects. Significant variations in the prevalence of OA in the VR were detected throughout the study period. In conclusion, a lower prevalence in SB and TOPFA was identified compared to EUROCAT data. As several studies have identified, an association between OA cases and birth weight was found.

Keywords: oesophageal atresia; prevalence; risk factors; prenatal diagnosis; epidemiology (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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