The Relationship of Left Ventricular Diastolic Dysfunction and Asymmetrical Dimethylarginine as a Biomarker of Endothelial Dysfunction with Cardiovascular Risk Assessed by Systematic Coronary Risk Evaluation2 Algorithm and Heart Failure—A Cross-Sectional Study

Livija Sušić (), Lana Maričić, Ines Šahinović, Kristina Kralik, Lucija Klobučar, Mateja Ćosić, Tihomir Sušić, Josip Vincelj, Antonio Burić, Marko Burić and Matea Lukić
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Livija Sušić: Department of Specialist-Consultative Health Care, Health Center of Osijek-Baranja County, 31000 Osijek, Croatia
Lana Maričić: Faculty of Medicine, University “Josip Juraj Strossmayer”, 31000 Osijek, Croatia
Ines Šahinović: Faculty of Medicine, University “Josip Juraj Strossmayer”, 31000 Osijek, Croatia
Kristina Kralik: Faculty of Medicine, University “Josip Juraj Strossmayer”, 31000 Osijek, Croatia
Lucija Klobučar: Faculty of Medicine, University “Josip Juraj Strossmayer”, 31000 Osijek, Croatia
Mateja Ćosić: Department of Specialist-Consultative Health Care, Health Center of Osijek-Baranja County, 31000 Osijek, Croatia
Tihomir Sušić: The Information Institute Osijek, 31000 Osijek, Croatia
Josip Vincelj: Faculty of Medicine, University “Josip Juraj Strossmayer”, 31000 Osijek, Croatia
Antonio Burić: Department of Radiology, Health Center of Osijek-Baranja County, 31000 Osijek, Croatia
Marko Burić: Faculty of Medicine, University “Josip Juraj Strossmayer”, 31000 Osijek, Croatia
Matea Lukić: Faculty of Medicine, University “Josip Juraj Strossmayer”, 31000 Osijek, Croatia

IJERPH, 2023, vol. 20, issue 5, 1-19

Abstract: Background: Cardiovascular (CV) risk factors, causing endothelial dysfunction (ED) and left ventricular diastolic dysfunction (LVDD), contribute to an increased risk of heart failure (HF). The aim of this study was to determine the relationship between the occurrence of LVDD and ED with CV risk assessed by the Systematic Coronary Risk Evaluation2 (SCORE2) algorithm and HF. Methods: In the period from November 2019 to May 2022, a cross-sectional study that included 178 middle-aged adults was conducted. Transthoracic echocardiography (TTE) was used to assess left ventricular (LV) diastolic and systolic function. ED was assessed using the plasma values of asymmetric dimethylarginine (ADMA) and was determined using the ELISA method. Results: The majority of subjects with LVDD grades 2 and 3 had high/very high SCORE2, developed HF and all were taking medication ( p < 0.001). They also had significantly lowest plasma ADMA values ( p < 0.001). We found that the reduction of ADMA concentration is influenced by certain groups of drugs, or more significantly, by their combinations ( p < 0.001). Conclusions: In our study, we confirmed a positive correlation between LVDD, HF and SCORE2 severity. The results showed a negative correlation between the biomarkers of ED, LVDD severity, HF, and SCORE2, which we believe is due to medication effects.

Keywords: amino terminal pro-brain natriuretic peptide; asymmetric dimethylarginine; cardiovascular diseases; diastole; drug therapy; endothelium; heart failure; middle aged; risk assessment (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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