Novel Approach for Glycemic Management Incorporating Vibration Stimulation of Skeletal Muscle in Obesity

Mijin Kim, Hanlin Zhang, Taeho Kim, Yutaro Mori, Tomohiro Okura, Kiyoji Tanaka, Tomonori Isobe, Takeji Sakae and Sechang Oh ()
Additional contact information
Mijin Kim: Institute of Food Research, National Agricultural and Food Research Organization, Tsukuba 305-8642, Japan
Hanlin Zhang: Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8572, Japan
Taeho Kim: The Center for Sports Medicine and Health Sciences, Tsukuba University Hospital, Tsukuba 305-8576, Japan
Yutaro Mori: Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
Tomohiro Okura: Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba 305-8572, Japan
Kiyoji Tanaka: Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba 305-8572, Japan
Tomonori Isobe: Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
Takeji Sakae: Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
Sechang Oh: Faculty of Rehabilitation, R Professional University of Rehabilitation, Tsuchiura 300-0032, Japan

IJERPH, 2023, vol. 20, issue 6, 1-12

Abstract: Because obesity is associated with impaired glucose tolerance and type 2 diabetes (T2D), it is important to manage the blood glucose level at an early stage. Nevertheless, people with obesity have significantly lower resistance to muscle fatigue after exercise and exercise adherence. Therefore, we developed a novel “Relaxing-Vibration Training ( R VT)” consisting of 25 postures using vibration stimulation of skeletal muscle and determined the feasibility of R VT for glycemic management. Thirty-one participants with obesity were enrolled in a controlled trial (CT) and experimental trial (ET) based on a 75 g oral glucose tolerance test (OGTT). During the CT, participants were required to rest in a quiet room. During the ET, the R VT program (50 Hz, 4 mm), consisting of 25 postures of relaxation and stretching on the vibratory platform, was performed for 40 min. Subsequently, the participants rested as in the CT. Subjective fatigue and muscle stiffness measurements and blood collection were conducted before and after R VT. In both the CT and ET, interstitial fluid (ISF) glucose concentrations were measured every 15 min for 2 h. The incremental area under the curve value of real-time ISF glucose during an OGTT was significantly lower in the ET than in the CT (ET: 7476.5 ± 2974.9, CT: 8078.5 ± 3077.7, effect size r = 0.4). Additionally, the levels of metabolic glucose regulators associated with myokines, muscle stiffness, and subjective fatigue significantly improved after R VT. This novel R VT suggests that it is effective in glycemic management with great potential to improve impaired glucose tolerance and T2D with obesity in the future.

Keywords: vibration therapy; obesity; impaired glucose tolerance; myokine; muscle stiffness (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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