Do Weight Changes Affect the Association between Smoking Cessation and the Risk of Stroke Subtypes in Korean Males?

Seulji Moon, Yeun Soo Yang, Heejin Kimm (), Keum Ji Jung, Ji Young Lee, Sun Ha Jee, Sunmi Lee, So Young Kim and Chung Mo Nam
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Seulji Moon: Department of Medicine, College of Medicine, Yonsei University, Seoul 03722, Republic of Korea
Yeun Soo Yang: Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 03722, Republic of Korea
Heejin Kimm: Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 03722, Republic of Korea
Keum Ji Jung: Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 03722, Republic of Korea
Ji Young Lee: Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 03722, Republic of Korea
Sun Ha Jee: Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 03722, Republic of Korea
Sunmi Lee: Health Insurance Policy Research Institute, National Health Insurance Service, Wonju 26464, Republic of Korea
So Young Kim: Health Insurance Policy Research Institute, National Health Insurance Service, Wonju 26464, Republic of Korea
Chung Mo Nam: Department of Medicine, College of Medicine, Yonsei University, Seoul 03722, Republic of Korea

IJERPH, 2023, vol. 20, issue 6, 1-15

Abstract: (1) Background: We investigated whether weight changes affect the association between smoking cessation and stroke risk; (2) Methods: Overall, 719,040 males were categorized into eight groups according to smoking status (sustained smokers, non-smokers, long-term quitters (quit > 4 years), and recent quitters (quit < 4 years)) and post-cessation weight change (−5 kg, −5.0 to 0.1 kg, maintainers, 0.1–5.0 kg, and >5.0 kg). The hazard ratios (HR) and 95% confidence intervals (CI) for incident total, ischemic, and hemorrhagic strokes, including subarachnoid and intracerebral hemorrhage, were calculated using Cox proportional hazard models; (3) Results: We detected 38,730 strokes (median follow-up, 25.7 years), including 30,609 ischemic and 9055 hemorrhagic strokes. For recent quitters with a >5.0 kg or 0.1–5.0 kg weight increase, maintainers, or those who lost 0.1–5 kg, the multivariable HR for total stroke was 0.73 (95% CI, 0.67–0.79), 0.78 (95% CI, 0.74–0.82), 0.77 (95% CI, 0.69–0.85), 0.84 (95% CI, 0.77–0.90), and 1.06 (95% CI, 0.92–1.23), respectively, compared with that of sustained smokers; (4) Conclusions: Comparable patterns were obtained for stroke subtypes. Thus, we strongly recommend quitting smoking, as weight gain after quitting smoking does not alter the stroke-related benefits.

Keywords: smoking cessation; weight gain; stroke (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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