Health Economic Evaluation of Proton Therapy for Lung Cancer: A Systematic Review

Chia-Chin Li, Ying-Chun Lin, Ji-An Liang, K. S. Clifford Chao, Te-Chun Hsia and Chun-Ru Chien ()
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Chia-Chin Li: Department of Radiation Oncology, China Medical University Hospital, Taichung 40402, Taiwan
Ying-Chun Lin: Department of Radiation Oncology, China Medical University Hospital, Taichung 40402, Taiwan
Ji-An Liang: Department of Radiation Oncology, China Medical University Hospital, Taichung 40402, Taiwan
K. S. Clifford Chao: Department of Radiation Oncology, China Medical University Hospital, Taichung 40402, Taiwan
Te-Chun Hsia: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung 40402, Taiwan
Chun-Ru Chien: Department of Radiation Oncology, China Medical University Hospital, Taichung 40402, Taiwan

IJERPH, 2023, vol. 20, issue 6, 1-10

Abstract: Background: To our knowledge, there have been no systematic reviews of health economic evaluations of proton therapy specific to lung cancer. Methods: We conducted this systematic review according to the predefined protocol [PROSPERO CRD42022365869]. We summarized the results of the included studies via structured narrative synthesis. Results: We identified four studies (all used passively scattered proton therapy) from 787 searches. Two cost analyses reported that proton therapy was more costly than photon therapy for early- or locally advanced-stage non-small cell lung cancer, one cost-utility analysis reported that proton therapy was dominated by nonproton therapy in early-stage non-small cell lung cancer, and one cost-utility analysis reported that proton therapy was not cost-effective (vs. photon) in locally advanced non-small cell lung cancer. Conclusions: Passively scattered proton therapy was more costly and not cost-effective than photon therapy for early- and locally advanced-stage non-small cell lung cancer. Further health economic evaluations regarding modern proton therapy (such as scanning beam) for common radiotherapy indications of lung cancer are eagerly awaited.

Keywords: health economic evaluation; lung cancer; proton therapy (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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