Preliminary Assessment of In Vivo Raman Spectroscopy Technique for Bone Quality Evaluation of Augmented Maxillary Sinus Floor

Eduard Gatin (), Pal Nagy, Stefan Marian Iordache, Ana-Maria Iordache (), Catalin Romeo Luculescu () and Valeriy Grygorovskyy
Additional contact information
Eduard Gatin: Faculty of Medicine, University of Medicine and Pharmacy “Carol Davila”, Blv. Eroii Sanitari 8, Sector 5, 050474 Bucharest, Romania
Pal Nagy: Faculty of Dentistry, Periodontology Department, Semmelweiss University, 1085 Budapest, Hungary
Stefan Marian Iordache: Optospintronics Department, National Institute for Research and Development for Optoelectronics—INOE 2000, 077125 Magurele, Romania
Ana-Maria Iordache: Optospintronics Department, National Institute for Research and Development for Optoelectronics—INOE 2000, 077125 Magurele, Romania
Catalin Romeo Luculescu: CETAL Department, National Institute for Laser, Plasma and Radiation Physics, Atomistilor Str. 409, 077125 Magurele, Romania
Valeriy Grygorovskyy: Research Institute for Traumatology and Orthopedics, 01601 Kyiv, Ukraine

IJERPH, 2023, vol. 20, issue 6, 1-13

Abstract: (1) Background: In oral surgery, bone regeneration is achieved through various types of bone grafts or bone substitutes and its success is usually analyzed by micro-computed tomography and histomorphometry. The aim of this study was to evaluate the usefulness of Raman spectroscopy as an alternative to other techniques for bone quality evaluation during a standard oral surgery procedure. (2) Methods: The preliminary evaluation of bone augmentation during maxillary sinus floor elevation oral surgery was performed by Raman spectroscopy for several (five) patients during and after the surgery and the results were compared with postoperative data from histomorphometry, EDX and SEM analysis. (3) Results: After analyzing all the results for the bone samples according to the four methods (Raman, EDX, SEM and Histology) that were used in our study, the obtained result of the investigation provided a good augmentation process for three of the patients and partly successful augmentation process for two of the patients. The primary evaluation using Raman spectroscopy (in vivo and ex vivo investigation) was confirmed by histological results, thus having a first step for validation of Raman as a new method of imaging for dentistry. (4) Conclusions: Our results show that Raman spectroscopy could provide fast and reliable insight on bone condition during augmentation of the maxillary sinus floor. We emphasize the advantages and drawbacks of the proposed techniques as its accuracy could increase by performing larger size clinical trials. Using the Raman mapping, the method can serve as an alternative to histology.

Keywords: Raman spectroscopy; histomorphology; in vivo/ex vivo bone evaluation; early diagnosis; biospectroscopy; oral regenerative surgery (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/20/6/4789/pdf (application/pdf)
https://www.mdpi.com/1660-4601/20/6/4789/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:20:y:2023:i:6:p:4789-:d:1091584

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().